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Cell Line Select

Streamline CDX model selection with powerful filters for tumor indication and genetic profile.

The Champions Oncology Cell Line Select Tool makes it simple to find the right models for your CDX studies. With just a few clicks, you can explore Champions’ panel of oncology cell lines and identify the models that best match your research needs.

Use the filters on the left to refine your search by Cell Line, Tumor Indication and Gene Mutation. For each cell line, you’ll also find gene expression data to help you make more informed choices.

Filters

22Rv1

Tumor Indication: Prostate
Mutated Genes
AR
Mutation: p.H875Y
Effect: Missense Variant
Impact: Pathogenic
ARID1A
Mutation: p.D1850GfsTer4
Effect: Frameshift Variant
ATM
Mutation: p.K1101E
Effect: Missense Variant
Impact: Uncertain Significance
BRAF
Mutation: p.L597R
Effect: Missense Variant
Impact: Pathogenic & Likely Pathogenic
BRCA2
Mutation: p.T3033NfsTer11
Effect: Frameshift Variant
Impact: Not Provided & Likely Pathogenic & Pathogenic
NOTCH2
Mutation: p.A1083SfsTer17
Effect: Frameshift Variant
Impact: Pathogenic
PIK3CA
Mutation: p.Q546R
Effect: Missense Variant
Impact: Pathogenic & Likely Pathogenic
TP53
Mutation: p.Q331R
Effect: Missense Variant, Splice Region Variant
Impact: Uncertain Significance
Mutation: p.V73WfsTer50
Effect: Frameshift Variant
Impact: Likely Pathogenic & Pathogenic
Lumin Data
Proteomics
View on Lumin View CDX Page

5637

Tumor Indication: Bladder
Mutated Genes
ATM
Mutation: p.H1876Q
Effect: Missense Variant
Impact: Uncertain Significance
ERBB2
Mutation: p.S310F
Effect: Missense Variant
Impact: Likely Pathogenic
TERT
Effect: Upstream Gene Variant
Impact: Pathogenic & Likely Pathogenic & Uncertain Significance
*Data provided by DepMap
TP53
Mutation: p.R280T
Effect: Missense Variant
Impact: Likely Pathogenic & Pathogenic
Lumin Data
Proteomics RNASeq WES
View on Lumin View CDX Page

786-O

Tumor Indication: Kidney
Mutated Genes
ATM
Mutation: p.R2436S
Effect: Missense Variant, Splice Region Variant
Impact: Uncertain Significance
TERT
Effect: Upstream Gene Variant
Impact: Pathogenic & Likely Pathogenic & Uncertain Significance
*Data provided by DepMap
TP53
Mutation: p.R248W
Effect: Missense Variant
Impact: Pathogenic / Likely Pathogenic & Pathogenic & Uncertain Significance & Likely Pathogenic
VHL
Mutation: p.G104AfsTer55
Effect: Frameshift Variant
*Data provided by DepMap
Lumin Data
Proteomics WES
View on Lumin View CDX Page

A-375

Tumor Indication: Melanoma
Mutated Genes
BRAF
Mutation: p.V600E
Effect: Missense Variant
Impact: Pathogenic & Likely Pathogenic & Not Provided
TERT
Effect: Upstream Gene Variant
Impact: Pathogenic
*Data provided by DepMap
Lumin Data
RNASeq WES
View on Lumin View CDX Page

A-431

Tumor Indication: Skin
Mutated Genes
ALK
Mutation: p.W582G
Effect: Missense Variant
Mutation: p.G872S
Effect: Missense Variant
Impact: Uncertain Significance
*Data provided by DepMap
TP53
Mutation: p.R273H
Effect: Missense Variant
Impact: Pathogenic / Likely Pathogenic & Pathogenic & Likely Pathogenic
Lumin Data
RNASeq WES
View on Lumin View CDX Page

A-498

Tumor Indication: Kidney
Mutated Genes
ALK
Mutation: p.G872S
Effect: Missense Variant
Impact: Uncertain Significance
*Data provided by DepMap
APC
Mutation: p.C1270R
Effect: Missense Variant
*Data provided by DepMap
VHL
Mutation: p.G144SfsTer14
Effect: Frameshift Variant
*Data provided by DepMap
View on Lumin View CDX Page

A549

Tumor Indication: Lung
Mutated Genes
ATR
Effect: Splice Acceptor Variant
Impact: Uncertain Significance & Likely Pathogenic
KRAS
Mutation: p.G12S
Effect: Missense Variant
Impact: Not Provided & Pathogenic
STK11
Mutation: p.Q37Ter
Effect: Stop-Gain
Impact: Likely Pathogenic & Pathogenic
Lumin Data
Proteomics RNASeq WES
View on Lumin View CDX Page

AsPC-1

Tumor Indication: Pancreatic
Mutated Genes
ARID1A
Mutation: p.H170TfsTer62
Effect: Frameshift Variant
*Data provided by DepMap
KRAS
Mutation: p.G12D
Effect: Missense Variant
Impact: Association & Pathogenic & Pathogenic / Likely Pathogenic & Likely Pathogenic & Not Provided
*Data provided by DepMap
TP53
Mutation: p.C135AfsTer35
Effect: Frameshift Variant
Impact: Pathogenic
*Data provided by DepMap
View on Lumin View CDX Page

BT-549

Tumor Indication: Breast
Mutated Genes
TP53
Mutation: p.R249S
Effect: Missense Variant
Impact: Uncertain Significance
Lumin Data
Proteomics RNASeq WES
View on Lumin View CDX Page

BxPC-3

Tumor Indication: Pancreatic
Mutated Genes
TP53
Mutation: p.Y220C
Effect: Missense Variant
Impact: Likely Pathogenic & Pathogenic
Lumin Data
Proteomics RNASeq WES
View on Lumin View CDX Page

Calu-6

Tumor Indication: Lung
Mutated Genes
KRAS
Mutation: p.Q61K
Effect: Missense Variant
*Data provided by DepMap
TP53
Mutation: p.R196Ter
Effect: Stop-Gain
Impact: Pathogenic
*Data provided by DepMap
View on Lumin View CDX Page

COLO 205

Tumor Indication: Bowel
Mutated Genes
APC
Mutation: p.T1556NfsTer3
Effect: Frameshift Variant
Impact: Pathogenic
ATM
Mutation: p.R189KfsTer17
Effect: Frameshift Variant
BRAF
Mutation: p.V600E
Effect: Missense Variant
Impact: Pathogenic & Likely Pathogenic & Not Provided
TP53
Mutation: p.Y103LfsTer42
Effect: Frameshift Variant
Mutation: p.Y107Ter
Effect: Frameshift Variant
Lumin Data
RNASeq WES
View on Lumin View CDX Page

Daudi

Tumor Indication: Lymphoid
Mutated Genes
FANCA
Mutation: p.S103Ter
Effect: Stop-Gain
Impact: Likely Pathogenic
TP53
Mutation: p.G266E
Effect: Missense Variant
Impact: Pathogenic / Likely Pathogenic & Likely Pathogenic & Uncertain Significance
Lumin Data
RNASeq WES
View on Lumin View CDX Page

Detroit 562

Tumor Indication: Pharyngeal
Mutated Genes
PIK3CA
Mutation: p.H1047R
Effect: Missense Variant
Impact: Pathogenic / Likely Pathogenic & Likely Pathogenic & Pathogenic
TP53
Mutation: p.R175H
Effect: Missense Variant
Impact: Not Provided & Likely Pathogenic & Pathogenic
View on Lumin View CDX Page

DLD-1

Tumor Indication: Colorectal
Mutated Genes
APC
Mutation: p.I1417LfsTer2
Effect: Frameshift Variant
*Data provided by DepMap
Mutation: p.K993N
Effect: Missense Variant
*Data provided by DepMap
Mutation: p.R2166Ter
Effect: Stop-Gain
Impact: Pathogenic
*Data provided by DepMap
Mutation: p.R727M
Effect: Missense Variant
*Data provided by DepMap
ARID1B
Mutation: p.G413Ter
Effect: Stop-Gain
*Data provided by DepMap
Mutation: p.R1747Ter
Effect: Stop-Gain
Impact: Pathogenic
*Data provided by DepMap
ATR
Mutation: p.I1851V
Effect: Missense Variant
*Data provided by DepMap
ATRX
Mutation: p.L629R
Effect: Missense Variant
*Data provided by DepMap
BRCA2
Mutation: p.C1200Ter
Effect: Frameshift Variant
Impact: Pathogenic
*Data provided by DepMap
Mutation: p.N1784TfsTer7
Effect: Frameshift Variant
Impact: Uncertain Significance & Not Provided & Pathogenic
*Data provided by DepMap
FANCA
Mutation: p.E1178Ter
Effect: Stop-Gain
*Data provided by DepMap
KRAS
Mutation: p.G13D
Effect: Missense Variant
Impact: Likely Pathogenic & Not Provided & Pathogenic & Uncertain Significance
*Data provided by DepMap
MSH6
Mutation: p.D1171Ter
Effect: Frameshift Variant
Impact: Pathogenic
*Data provided by DepMap
Mutation: p.L290Ter
Effect: Frameshift Variant
Impact: Pathogenic
*Data provided by DepMap
Mutation: p.R1172del
Effect: Inframe Deletion
*Data provided by DepMap
PIK3CA
Mutation: p.D549N
Effect: Missense Variant
Impact: Pathogenic
*Data provided by DepMap
Mutation: p.E545K
Effect: Missense Variant
Impact: Not Provided & Likely Pathogenic & Pathogenic & Pathogenic / Likely Pathogenic
*Data provided by DepMap
TP53
Mutation: p.S241F
Effect: Missense Variant
Impact: Likely Pathogenic & Pathogenic / Likely Pathogenic & Pathogenic
*Data provided by DepMap
Effect: Splice Acceptor Variant
Impact: Not Provided
*Data provided by DepMap
Lumin Data
Proteomics
View on Lumin View CDX Page

DMS 114

Tumor Indication: Lung
Mutated Genes
TP53
Mutation: p.R213Ter
Effect: Stop-Gain
Impact: Pathogenic
Lumin Data
RNASeq WES
View on Lumin View CDX Page

DoHH2

Tumor Indication: Lymphoma
Lumin Data
Proteomics RNASeq WES
View on Lumin View CDX Page

DU 145

Tumor Indication: Prostate
Mutated Genes
MLH1
Effect: Splice Acceptor Variant
Impact: Likely Pathogenic & Pathogenic
NF2
Mutation: p.E394del
Effect: Inframe Deletion
NOTCH2
Mutation: p.A1083SfsTer17
Effect: Frameshift Variant
Impact: Pathogenic
RET
Mutation: p.V804M
Effect: Missense Variant
Impact: Likely Pathogenic & Pathogenic & Pathogenic / Likely Pathogenic
STK11
Mutation: p.K178GfsTer86
Effect: Frameshift Variant
TP53
Mutation: p.P223L
Effect: Missense Variant
Impact: Uncertain Significance
Mutation: p.V274F
Effect: Missense Variant
Impact: Pathogenic & Uncertain Significance & Likely Pathogenic
Lumin Data
RNASeq WES
View on Lumin View CDX Page

FaDu

Tumor Indication: Head and Neck
Mutated Genes
TP53
Mutation: p.R248L
Effect: Missense Variant
Impact: Likely Pathogenic & Pathogenic
Effect: Splice Acceptor Variant
Impact: Pathogenic
VHL
Mutation: p.M1?
Effect: Start-Loss
Impact: Uncertain Significance & Conflicting Interpretations Of Pathogenicity
Lumin Data
Proteomics RNASeq WES
View on Lumin View CDX Page

Granta-519

Tumor Indication: Lymphoma
Mutated Genes
ATM
Mutation: p.R2832C
Effect: Missense Variant
Impact: Likely Pathogenic & Pathogenic & Pathogenic / Likely Pathogenic
Effect: Splice Acceptor Variant
Impact: Not Provided
TYRO3
Mutation: p.K235AfsTer18
Effect: Frameshift Variant, Splice Region Variant
Lumin Data
Proteomics RNASeq WES
View on Lumin View CDX Page

HCC1806

Tumor Indication: Breast
Mutated Genes
TP53
Mutation: p.T256KfsTer90
Effect: Frameshift Variant
*Data provided by DepMap
View on Lumin View CDX Page

HCT 116

Tumor Indication: Colorectal
Mutated Genes
ABL1
Mutation: p.Y257C
Effect: Missense Variant
ATRX
Mutation: p.T1529del
Effect: Inframe Deletion
BRCA2
Mutation: p.I2675DfsTer6
Effect: Frameshift Variant
Impact: Pathogenic
CTNNB1
Mutation: p.S45del
Effect: Inframe Deletion
Impact: Pathogenic & Other
FANCA
Mutation: p.P615HfsTer25
Effect: Frameshift Variant
KRAS
Mutation: p.G13D
Effect: Missense Variant
Impact: Likely Pathogenic & Not Provided & Pathogenic & Uncertain Significance
MERTK
Mutation: p.R722Ter
Effect: Stop-Gain
Impact: Pathogenic & Likely Pathogenic
MLH1
Mutation: p.S252Ter
Effect: Stop-Gain
Impact: Pathogenic
MSH6
Mutation: p.F1088LfsTer5
Effect: Frameshift Variant
Impact: Likely Pathogenic & Pathogenic
PIK3CA
Mutation: p.H1047R
Effect: Missense Variant
Impact: Pathogenic / Likely Pathogenic & Likely Pathogenic & Pathogenic
Lumin Data
RNASeq WES
View on Lumin View CDX Page

HeLa

Tumor Indication: Cervical
Lumin Data
RNASeq WES
View on Lumin View CDX Page

Hep 3B2.1-7

Tumor Indication: Hepatocellular Carcinoma
View on Lumin View CDX Page

Hep G2

Tumor Indication: Hepatocellular Carcinoma
Mutated Genes
NRAS
Mutation: p.Q61L
Effect: Missense Variant
Impact: Likely Pathogenic & Pathogenic & Uncertain Significance
TERT
Effect: Upstream Gene Variant
Impact: Pathogenic & Likely Pathogenic & Uncertain Significance
*Data provided by DepMap
Lumin Data
RNASeq WES
View on Lumin View CDX Page

Hs 695T

Tumor Indication: Skin
Mutated Genes
ATM
Mutation: p.Q1825Ter
Effect: Stop-Gain
Impact: Pathogenic
*Data provided by DepMap
BRAF
Mutation: p.V600E
Effect: Missense Variant
Impact: Pathogenic & Likely Pathogenic & Not Provided
*Data provided by DepMap
NF1
Mutation: p.Q959Ter
Effect: Stop-Gain
Impact: Pathogenic
*Data provided by DepMap
TERT
Effect: Upstream Gene Variant
Impact: Pathogenic
*Data provided by DepMap
View on Lumin View CDX Page

HT-1080

Tumor Indication: Sarcoma
Mutated Genes
IDH1
Mutation: p.R132C
Effect: Missense Variant
Impact: Pathogenic / Likely Pathogenic & Likely Pathogenic & Pathogenic
NRAS
Mutation: p.Q61K
Effect: Missense Variant
Impact: Uncertain Significance & Drug Response & Likely Pathogenic & Not Provided & Pathogenic
Lumin Data
RNASeq WES
View on Lumin View CDX Page

HT-1376

Tumor Indication: Bladder
Mutated Genes
ARID1A
Mutation: p.S186RfsTer209
Effect: Frameshift Variant
*Data provided by DepMap
TERT
Effect: Upstream Gene Variant
Impact: Pathogenic & Likely Pathogenic & Uncertain Significance
*Data provided by DepMap
TP53
Mutation: p.P250L
Effect: Missense Variant
Impact: Uncertain Significance & Likely Pathogenic & Pathogenic / Likely Pathogenic
*Data provided by DepMap
View on Lumin View CDX Page

HT-29

Tumor Indication: Colorectal
Mutated Genes
APC
Mutation: p.E853Ter
Effect: Stop-Gain
Impact: Pathogenic
Mutation: p.T1556NfsTer3
Effect: Frameshift Variant
Impact: Pathogenic
BRAF
Mutation: p.V600E
Effect: Missense Variant
Impact: Pathogenic & Likely Pathogenic & Not Provided
PIK3CA
Mutation: p.P449T
Effect: Missense Variant
Impact: Pathogenic / Likely Pathogenic
SMAD4
Mutation: p.Q311Ter
Effect: Stop-Gain
Impact: Pathogenic
TP53
Mutation: p.R273H
Effect: Missense Variant
Impact: Pathogenic / Likely Pathogenic & Pathogenic & Likely Pathogenic
Lumin Data
Proteomics RNASeq WES
View on Lumin View CDX Page

Huh-7

Tumor Indication: Liver
Mutated Genes
TERT
Effect: Upstream Gene Variant
Impact: Pathogenic & Likely Pathogenic & Uncertain Significance
*Data provided by DepMap
TP53
Mutation: p.Y220C
Effect: Missense Variant
Impact: Likely Pathogenic & Pathogenic
*Data provided by DepMap
View on Lumin View CDX Page

JEG-3

Tumor Indication: Uterine
View on Lumin View CDX Page

JeKo-1

Tumor Indication: Lymphoma
Mutated Genes
ATRX
Mutation: p.R246C
Effect: Missense Variant
Impact: Pathogenic & Pathogenic / Likely Pathogenic & Not Provided
TP53
Mutation: p.P58QfsTer65
Effect: Frameshift Variant
Impact: Pathogenic
Lumin Data
RNASeq WES
View on Lumin View CDX Page

JIMT-1

Tumor Indication: Breast
Mutated Genes
PIK3CA
Mutation: p.C420R
Effect: Missense Variant
Impact: Likely Pathogenic & Pathogenic
TP53
Mutation: p.R248W
Effect: Missense Variant
Impact: Pathogenic / Likely Pathogenic & Pathogenic & Uncertain Significance & Likely Pathogenic
Lumin Data
Proteomics
View on Lumin View CDX Page

LNCaP clone FGC

Tumor Indication: Prostate
Mutated Genes
ABL1
Mutation: p.N770S
Effect: Missense Variant
APC
Mutation: p.R2714C
Effect: Missense Variant
Impact: Uncertain Significance
AR
Mutation: p.T878A
Effect: Missense Variant
Impact: Pathogenic
ARID1A
Mutation: p.G285EfsTer78
Effect: Frameshift Variant
ARID1B
Mutation: p.E2287Ter
Effect: Stop-Gain
ATRX
Mutation: p.E2265del
Effect: Inframe Deletion
TERT
Mutation: p.R865C
Effect: Missense Variant
Impact: Likely Pathogenic & Uncertain Significance
*Data provided by DepMap
Lumin Data
RNASeq WES
View on Lumin View CDX Page

LoVo

Tumor Indication: Bowel
Mutated Genes
ALK
Mutation: p.G1580V
Effect: Missense Variant
*Data provided by DepMap
APC
Mutation: p.M1431CfsTer42
Effect: Frameshift Variant
Impact: Pathogenic
*Data provided by DepMap
Mutation: p.R1114Ter
Effect: Stop-Gain
Impact: Pathogenic & Likely Pathogenic
*Data provided by DepMap
Mutation: p.R2816Q
Effect: Missense Variant
Impact: Conflicting Interpretations Of Pathogenicity & Uncertain Significance
*Data provided by DepMap
ARID1A
Mutation: p.F2141SfsTer59
Effect: Frameshift Variant
*Data provided by DepMap
KRAS
Mutation: p.G13D
Effect: Missense Variant
Impact: Likely Pathogenic & Not Provided & Pathogenic & Uncertain Significance
*Data provided by DepMap
View on Lumin View CDX Page

MIA PaCa-2

Tumor Indication: Pancreatic
Mutated Genes
ARID1A
Mutation: p.Q321Ter
Effect: Stop-Gain
KRAS
Mutation: p.G12C
Effect: Missense Variant
Impact: Likely Pathogenic & Pathogenic & Not Provided & Pathogenic / Likely Pathogenic
TP53
Mutation: p.R248W
Effect: Missense Variant
Impact: Pathogenic / Likely Pathogenic & Pathogenic & Uncertain Significance & Likely Pathogenic
Lumin Data
RNASeq WES
View on Lumin View CDX Page

MKN-45

Tumor Indication: Esophageal, Gastric
Mutated Genes
ARID1A
Mutation: p.Q321GfsTer70
Effect: Frameshift Variant
TP53
Mutation: p.R110C
Effect: Missense Variant
Impact: Uncertain Significance
Lumin Data
Proteomics RNASeq WES
View on Lumin View CDX Page

MM.1R

Tumor Indication: Lymphoid
Lumin Data
RNASeq WES
View on Lumin View CDX Page

MM.1S

Tumor Indication: Lymphoid
Mutated Genes
KRAS
Mutation: p.G12A
Effect: Missense Variant
Impact: Pathogenic & Not Provided & Likely Pathogenic
Lumin Data
RNASeq WES
View on Lumin View CDX Page

NCI-H1373

Tumor Indication: Lung
Mutated Genes
ATM
Mutation: p.E2943Ter
Effect: Stop-Gain
KRAS
Mutation: p.G12C
Effect: Missense Variant
Impact: Likely Pathogenic & Pathogenic & Not Provided & Pathogenic / Likely Pathogenic
TP53
Mutation: p.E339Ter
Effect: Stop-Gain
Impact: Pathogenic
Lumin Data
Proteomics RNASeq WES
View on Lumin View CDX Page

NCI-H1975

Tumor Indication: Lung
Mutated Genes
EGFR
Mutation: p.L858R
Effect: Missense Variant
Impact: Pathogenic & Drug Response
*Data provided by DepMap
Mutation: p.T790M
Effect: Missense Variant
Impact: Pathogenic / Likely Pathogenic & Protective & Pathogenic & Drug Response & Likely Pathogenic
*Data provided by DepMap
PIK3CA
Mutation: p.G118D
Effect: Missense Variant, Splice Region Variant
Impact: Likely Pathogenic & Pathogenic
*Data provided by DepMap
TP53
Mutation: p.R273H
Effect: Missense Variant
Impact: Pathogenic / Likely Pathogenic & Pathogenic & Likely Pathogenic
*Data provided by DepMap
View on Lumin View CDX Page

NCI-H460

Tumor Indication: Lung
Mutated Genes
ARID1A
Mutation: p.I2135_L2136del
Effect: Inframe Deletion
*Data provided by DepMap
KRAS
Mutation: p.Q61H
Effect: Missense Variant
Impact: Pathogenic & Likely Pathogenic
*Data provided by DepMap
PIK3CA
Mutation: p.E545K
Effect: Missense Variant
Impact: Not Provided & Likely Pathogenic & Pathogenic & Pathogenic / Likely Pathogenic
*Data provided by DepMap
STK11
Mutation: p.Q37Ter
Effect: Stop-Gain
Impact: Likely Pathogenic & Pathogenic
*Data provided by DepMap
View on Lumin View CDX Page

NCI-H82

Tumor Indication: Lung
Mutated Genes
TP53
Mutation: p.T125=
Effect: Splice Region Variant, Synonymous Variant
Impact: Not Provided & Pathogenic
*Data provided by DepMap
View on Lumin View CDX Page

NCI-H929

Tumor Indication: Lymphoid
Mutated Genes
ATM
Mutation: p.E347K
Effect: Missense Variant
NRAS
Mutation: p.G13D
Effect: Missense Variant
Impact: Likely Pathogenic & Pathogenic
Lumin Data
Proteomics RNASeq WES
View on Lumin View CDX Page

NCI-N87

Tumor Indication: Esophageal, Gastric
Mutated Genes
TP53
Mutation: p.R248Q
Effect: Missense Variant
Impact: Pathogenic / Likely Pathogenic & Likely Pathogenic & Pathogenic
Lumin Data
Proteomics RNASeq WES
View on Lumin View CDX Page

OV-90

Tumor Indication: Ovarian
Mutated Genes
SMAD4
Mutation: p.R445Ter
Effect: Stop-Gain
Impact: Pathogenic
*Data provided by DepMap
TP53
Mutation: p.S215R
Effect: Missense Variant
Impact: Likely Pathogenic & Uncertain Significance
Lumin Data
Proteomics RNASeq WES
View on Lumin View CDX Page

OVCAR-3

Tumor Indication: Ovarian
View on Lumin View CDX Page

PANC-1

Tumor Indication: Pancreatic
Mutated Genes
KRAS
Mutation: p.G12D
Effect: Missense Variant
Impact: Association & Pathogenic & Pathogenic / Likely Pathogenic & Likely Pathogenic & Not Provided
TP53
Mutation: p.R273H
Effect: Missense Variant
Impact: Pathogenic / Likely Pathogenic & Pathogenic & Likely Pathogenic
Lumin Data
Proteomics
View on Lumin View CDX Page

PC-3

Tumor Indication: Prostate
Mutated Genes
TP53
Mutation: p.K139RfsTer31
Effect: Frameshift Variant
Impact: Not Provided
View on Lumin View CDX Page

RAJI

Tumor Indication: Lymphoma
Mutated Genes
TP53
Mutation: p.R213Q
Effect: Missense Variant
Impact: Likely Pathogenic & Pathogenic & Drug Response & Not Provided
Mutation: p.Y234H
Effect: Missense Variant
Impact: Pathogenic & Likely Pathogenic
Lumin Data
RNASeq WES
View on Lumin View CDX Page

RKO

Tumor Indication: Colorectal
Mutated Genes
ABL1
Mutation: p.F747I
Effect: Missense Variant
*Data provided by DepMap
ARID1A
Mutation: p.D1850TfsTer33
Effect: Frameshift Variant
*Data provided by DepMap
Mutation: p.P1115QfsTer46
Effect: Frameshift Variant
*Data provided by DepMap
BRAF
Mutation: p.V600E
Effect: Missense Variant
Impact: Pathogenic & Likely Pathogenic & Not Provided
*Data provided by DepMap
BRCA2
Mutation: p.N1784TfsTer7
Effect: Frameshift Variant
Impact: Uncertain Significance & Not Provided & Pathogenic
*Data provided by DepMap
BRD4
Mutation: p.T295P
Effect: Missense Variant
Impact: Pathogenic & Uncertain Significance
*Data provided by DepMap
FANCA
Mutation: p.E345VfsTer63
Effect: Frameshift Variant
*Data provided by DepMap
NF1
Mutation: p.N2341TfsTer5
Effect: Frameshift Variant
*Data provided by DepMap
Mutation: p.Y628TfsTer3
Effect: Frameshift Variant
*Data provided by DepMap
NF2
Mutation: p.P275HfsTer21
Effect: Frameshift Variant
*Data provided by DepMap
PIK3CA
Mutation: p.H1047R
Effect: Missense Variant
Impact: Pathogenic / Likely Pathogenic & Likely Pathogenic & Pathogenic
*Data provided by DepMap
View on Lumin View CDX Page

RPMI 8226

Tumor Indication: Lymphoid
Mutated Genes
EGFR
Mutation: p.T751I
Effect: Missense Variant
Impact: Drug Response
KRAS
Mutation: p.G12A
Effect: Missense Variant
Impact: Pathogenic & Not Provided & Likely Pathogenic
TP53
Mutation: p.E285K
Effect: Missense Variant
Impact: Likely Pathogenic & Pathogenic & Drug Response & Pathogenic / Likely Pathogenic
View on Lumin View CDX Page

SHP-77

Tumor Indication: Lung
Mutated Genes
KRAS
Mutation: p.G12V
Effect: Missense Variant
Impact: Likely Pathogenic & Pathogenic
*Data provided by DepMap
TP53
Mutation: p.C176W
Effect: Missense Variant
Impact: Likely Pathogenic & Uncertain Significance
*Data provided by DepMap
Lumin Data
Proteomics
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SK-MEL-5

Tumor Indication: Skin
Mutated Genes
BRAF
Mutation: p.V600E
Effect: Missense Variant
Impact: Pathogenic & Likely Pathogenic & Not Provided
TERT
Effect: Upstream Gene Variant
*Data provided by DepMap
Lumin Data
Proteomics RNASeq WES
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SK-N-MC

Tumor Indication: Sarcoma
Lumin Data
Proteomics RNASeq WES
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SK-OV-3

Tumor Indication: Ovarian, Fallopian Tube
Mutated Genes
ARID1A
Mutation: p.Q586Ter
Effect: Stop-Gain
ATM
Effect: Splice Acceptor Variant
Impact: Likely Pathogenic & Uncertain Significance
PIK3CA
Mutation: p.H1047R
Effect: Missense Variant
Impact: Pathogenic / Likely Pathogenic & Likely Pathogenic & Pathogenic
TP53
Mutation: p.S90PfsTer33
Effect: Frameshift Variant
Impact: Likely Pathogenic & Pathogenic
Lumin Data
Proteomics RNASeq WES
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SK-UT-1

Tumor Indication: Uterine
Mutated Genes
ALK
Mutation: p.R1192Q
Effect: Missense Variant
Impact: Uncertain Significance
APC
Mutation: p.Q1096Ter
Effect: Stop-Gain
Impact: Pathogenic
Mutation: p.T1556LfsTer9
Effect: Frameshift Variant
Impact: Pathogenic
ARID1A
Mutation: p.G276EfsTer87
Effect: Frameshift Variant
Mutation: p.P1326RfsTer155
Effect: Frameshift Variant
ARID1B
Mutation: p.Q1982Ter
Effect: Stop-Gain
Mutation: p.Q2157Ter
Effect: Stop-Gain
Impact: Pathogenic
MSH2
Mutation: p.T788SfsTer10
Effect: Frameshift Variant
Impact: Likely Pathogenic
PIK3CA
Mutation: p.R88Q
Effect: Missense Variant
Impact: Pathogenic & Likely Pathogenic
TP53
Mutation: p.R175H
Effect: Missense Variant
Impact: Not Provided & Likely Pathogenic & Pathogenic
Mutation: p.R248Q
Effect: Missense Variant
Impact: Pathogenic / Likely Pathogenic & Likely Pathogenic & Pathogenic
TSC2
Mutation: p.Q90Ter
Effect: Stop-Gain
Impact: Pathogenic & Not Provided
Lumin Data
Proteomics RNASeq WES
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SNU-16

Tumor Indication: Gastric
Mutated Genes
ARID1A
Effect: Splice Donor Variant
*Data provided by DepMap
TP53
Mutation: p.Y205F
Effect: Missense Variant
Impact: Likely Pathogenic
*Data provided by DepMap
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SNU-5

Tumor Indication: Gastric
Lumin Data
Proteomics RNASeq WES
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SU-DHL-2

Tumor Indication: Lymphoma
Mutated Genes
TP53
Mutation: p.Y234S
Effect: Missense Variant
Impact: Uncertain Significance & Likely Pathogenic
Lumin Data
Proteomics RNASeq WES
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SU-DHL-4

Tumor Indication: Lymphoma
Mutated Genes
EZH2
Mutation: p.Y646S
Effect: Missense Variant
Impact: Likely Pathogenic
TP53
Mutation: p.R273C
Effect: Missense Variant
Impact: Uncertain Significance & Not Provided & Likely Pathogenic & Pathogenic & Pathogenic / Likely Pathogenic
Lumin Data
Proteomics RNASeq WES
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SU-DHL-6

Tumor Indication: Lymphoma
Mutated Genes
ARID1A
Mutation: p.Q200Ter
Effect: Stop-Gain
EZH2
Mutation: p.Y646N
Effect: Missense Variant
Impact: Likely Pathogenic
TP53
Mutation: p.Y234C
Effect: Missense Variant
Impact: Pathogenic / Likely Pathogenic & Likely Pathogenic
Effect: Splice Acceptor Variant
Impact: Pathogenic & Likely Pathogenic & Not Provided
Lumin Data
Proteomics RNASeq WES
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SU-DHL-8

Tumor Indication: Lymphoma
Mutated Genes
BRAF
Mutation: p.T599dup
Effect: Inframe Insertion
Impact: Pathogenic
TP53
Mutation: p.R249G
Effect: Missense Variant
Impact: Likely Pathogenic & Uncertain Significance & Conflicting Interpretations Of Pathogenicity
Mutation: p.Y234N
Effect: Missense Variant
Impact: Pathogenic & Likely Pathogenic
Lumin Data
Proteomics RNASeq WES
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SW480

Tumor Indication: Colorectal
Mutated Genes
APC
Mutation: p.Q1338Ter
Effect: Stop-Gain
Impact: Pathogenic & Likely Pathogenic
ATM
Mutation: p.R2461P
Effect: Missense Variant
Impact: Uncertain Significance
KRAS
Mutation: p.G12V
Effect: Missense Variant
Impact: Likely Pathogenic & Pathogenic
TP53
Mutation: p.P309S
Effect: Missense Variant
Impact: Uncertain Significance
Mutation: p.R273H
Effect: Missense Variant
Impact: Pathogenic / Likely Pathogenic & Pathogenic & Likely Pathogenic
Lumin Data
Proteomics RNASeq WES
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SW620

Tumor Indication: Colorectal
Mutated Genes
APC
Mutation: p.Q1338Ter
Effect: Stop-Gain
Impact: Pathogenic & Likely Pathogenic
KRAS
Mutation: p.G12V
Effect: Missense Variant
Impact: Likely Pathogenic & Pathogenic
TP53
Mutation: p.P309S
Effect: Missense Variant
Impact: Uncertain Significance
Mutation: p.R273H
Effect: Missense Variant
Impact: Pathogenic / Likely Pathogenic & Pathogenic & Likely Pathogenic
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THP-1

Tumor Indication: Leukemia
Mutated Genes
NRAS
Mutation: p.G12D
Effect: Missense Variant
Impact: Likely Pathogenic & Pathogenic & Pathogenic / Likely Pathogenic
TP53
Mutation: p.R174LfsTer3
Effect: Frameshift Variant
Lumin Data
RNASeq WES
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U-87 MG

Tumor Indication: Glioblastoma
Mutated Genes
ATRX
Mutation: p.N564S
Effect: Missense Variant
*Data provided by DepMap
NF1
Mutation: p.F1247IfsTer18
Effect: Frameshift Variant
Impact: Pathogenic
*Data provided by DepMap
TERT
Effect: Upstream Gene Variant
Impact: Pathogenic & Likely Pathogenic & Uncertain Significance
*Data provided by DepMap
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UM-UC-14

Tumor Indication: Kidney
Mutated Genes
FGFR3
Mutation: p.S249C
Effect: Missense Variant
Impact: Likely Pathogenic & Pathogenic
*Data provided by DepMap
PIK3CA
Mutation: p.E418K
Effect: Missense Variant, Splice Region Variant
Impact: Likely Pathogenic & Pathogenic & Uncertain Significance
*Data provided by DepMap
TP53
Mutation: p.R280T
Effect: Missense Variant
Impact: Likely Pathogenic & Pathogenic
*Data provided by DepMap
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VCaP

Tumor Indication: Prostate
Mutated Genes
MSH6
Mutation: p.F1088LfsTer5
Effect: Frameshift Variant
Impact: Likely Pathogenic & Pathogenic
TP53
Mutation: p.R248W
Impact: Pathogenic / Likely Pathogenic & Pathogenic & Uncertain Significance & Likely Pathogenic
Lumin Data
Proteomics
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Mutation Data Sources
Expression Data Sources

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