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Cell Line Select

Streamline CDX model selection with powerful filters for tumor indication and genetic profile.

The Champions Oncology Cell Line Select Tool makes it simple to find the right models for your CDX studies. With just a few clicks, you can explore Champions’ panel of oncology cell lines and identify the models that best match your research needs.

Use the filters on the left to refine your search by Cell Line, Tumor Indication and Gene Mutation. For each cell line, you’ll also find gene expression data to help you make more informed choices.

Filters

22Rv1

Tumor Indication: Prostate
Mutated Genes
AR
Mutation: H875Y
Effect: Missense
Impact: Pathogenic
ARID1A
Mutation: D1850fs*4
Effect: Frameshift
Impact: Cancer Driver
Mutation: P1326fs*155
Effect: Frameshift
Impact: Cancer Driver
Mutation: D1850GfsTer4
Effect: Frameshift
Impact: High Tumor Suppressor Impact
AXL
Mutation: L180PfsTer30
Effect: Frameshift
Impact: High Oncogene Impact
BRAF
Mutation: L597R
Effect: Missense
Impact: Pathogenic
BRCA2
Mutation: T3033fs*11
Effect: Frameshift
Impact: Cancer Driver
Mutation: T3033NfsTer11
Effect: Frameshift
Impact: High Tumor Suppressor Impact
JAK1
Mutation: K142fs*26
Effect: Frameshift
Impact: Cancer Driver
Mutation: K142RfsTer26
Effect: Frameshift
Impact: High Oncogene Impact
Mutation: L431VfsTer22
Effect: Frameshift
Impact: High Oncogene Impact
KDM5A
Mutation: P593L
Effect: Missense
Impact: Deleterious
MTOR
Mutation: R1749Q
Effect: Missense, Splice Region Variant
Impact: Probably Damaging
NOTCH2
Mutation: E710fs*33
Effect: Frameshift
Impact: Cancer Driver
Mutation: E710RfsTer33
Effect: Frameshift
Impact: High Oncogene Impact
Mutation: A1083SfsTer17
Effect: Frameshift
Impact: Pathogenic
PDGFRA
Mutation: W57R
Effect: Missense
Impact: Deleterious
PIK3CA
Mutation: Q546R
Effect: Missense
Impact: Pathogenic
RB1
Mutation: Splice variant
Effect: ESS Splice Varient
Impact: Cancer Driver
ROS1
Mutation: Splice variant
Effect: Splice Donor Variant
Impact: High Oncogene Impact
TP53
Mutation: V73fs*50
Effect: Frameshift
Impact: Cancer Driver
Mutation: V73WfsTer50
Effect: Frameshift
Impact: Likely Pathogenic
TSC1
Mutation: Splice variant
Effect: Splice Acceptor Variant
Impact: High Tumor Suppressor Impact
Lumin Data
Proteomics
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5637

Tumor Indication: Bladder
Mutated Genes
CDKN2C
Mutation: A61V
Effect: Missense
Impact: Deleterious
ERBB2
Mutation: S310F
Effect: Missense
Impact: Likely Pathogenic
HGF
Mutation: E159K
Effect: Missense
Impact: Deleterious
KDM5A
Mutation: W139Ter
Effect: Stop-Gain
Impact: High Oncogene Impact
MLH1
Mutation: K618A
Effect: Missense
Impact: Deleterious
NF2
Mutation: W184R
Effect: Missense
Impact: Probably Damaging
RB1
Mutation: Y325Ter
Effect: Stop-Gain
Impact: High Tumor Suppressor Impact
TP53
Mutation: R280T
Effect: Missense
Impact: Likely Pathogenic
Lumin Data
Proteomics RNASeq WES
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A-375

Tumor Indication: Melanoma
Mutated Genes
BRAF
Mutation: V600E
Effect: Missense
Impact: Cancer Driver
Mutation: V600E
Effect: Missense
Impact: Pathogenic
CDKN2A
Mutation: E61*
Effect: Nonsense
Impact: Cancer Driver
Mutation: E61Ter
Effect: Stop-Gain
Impact: Likely Pathogenic
Mutation: E69Ter
Effect: Stop-Gain
Impact: Likely Pathogenic
FGFR2
Mutation: E636K
Effect: Missense
Impact: Probably Damaging
HGF
Mutation: D462Y
Effect: Missense
Impact: Cancer Driver
Mutation: D462Y
Effect: Missense
Impact: Deleterious
LATS2
Mutation: T431I
Effect: Missense
Impact: Deleterious
Lumin Data
RNASeq WES
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A-431

Tumor Indication: Skin
Mutated Genes
ALK
Mutation: W582G
Effect: Missense
Impact: Deleterious
AXL
Mutation: G626Ter
Effect: Stop-Gain
Impact: High Oncogene Impact
LATS2
Mutation: Q650H
Effect: Missense
Impact: Deleterious
ROS1
Mutation: S407Ter
Effect: Stop-Gain
Impact: High Oncogene Impact
TP53
Mutation: R273H
Effect: Missense
Impact: Cancer Driver
Mutation: R273H
Effect: Missense
Impact: Pathogenic
Lumin Data
RNASeq WES
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A549

Tumor Indication: Lung
Mutated Genes
ATR
Mutation: Splice variant
Effect: ESS Splice Varient
Impact: Cancer Driver
Mutation: Splice variant
Effect: Splice Acceptor Variant
Impact: High Tumor Suppressor Impact
KEAP1
Mutation: G333C
Effect: Missense
Impact: Deleterious
KRAS
Mutation: G12S
Effect: Missense
Impact: Deleterious
STK11
Mutation: Q37Ter
Effect: Stop-Gain
Impact: Likely Pathogenic
Lumin Data
Proteomics RNASeq WES
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AsPC-1

Tumor Indication: Pancreatic
Mutated Genes
ARID1A
Mutation: H170TfsTer62
Effect: Frameshift
Impact: High Tumor Suppressor Impact
CDKN2A
Mutation: L78fs*41
Effect: Frameshift
Impact: Cancer Driver
Mutation: L78HfsTer41
Effect: Frameshift
Impact: High Tumor Suppressor Impact
KRAS
Mutation: G12D
Effect: Missense
Impact: Likely Pathogenic
SMAD4
Mutation: R100T
Effect: Missense
Impact: Probably Damaging
TP53
Mutation: C135fs*35
Effect: Frameshift
Impact: Cancer Driver
Mutation: C135AfsTer35
Effect: Frameshift
Impact: Pathogenic
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BT-549

Tumor Indication: Breast
Mutated Genes
PTEN
Mutation: V275fs*1
Effect: Frameshift
Impact: Cancer Driver
Mutation: V275Ter
Effect: Frameshift
Impact: Pathogenic
TP53
Mutation: R249S
Effect: Missense
Impact: Deleterious
Lumin Data
Proteomics RNASeq WES
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BxPC-3

Tumor Indication: Pancreatic
Mutated Genes
TP53
Mutation: Y220C
Effect: Missense
Impact: Likely Pathogenic
Lumin Data
Proteomics RNASeq WES
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COLO 205

Tumor Indication: Bowel
Mutated Genes
APC
Mutation: T1556NfsTer3
Effect: Frameshift
Impact: Pathogenic
Mutation: T1556fs*3
Effect: Frameshift
Impact: Cancer Driver
ATM
Mutation: R189KfsTer17
Effect: Frameshift
Impact: High Tumor Suppressor Impact
BRAF
Mutation: V600E
Effect: Missense
Impact: Pathogenic
Mutation: V600E
Effect: Missense
Impact: Cancer Driver
FGFR4
Mutation: T181P
Effect: Missense
Impact: Possibly Damaging
FLT4
Mutation: E365PfsTer60
Effect: Frameshift
Impact: High Oncogene Impact
Mutation: Splice variant
Effect: Splice Donor Variant
Impact: High Oncogene Impact
KDR
Mutation: Y801Ter
Effect: Stop-Gain
Impact: High Oncogene Impact
MTOR
Mutation: P1193L
Effect: Missense
Impact: Possibly Damaging
TP53
Mutation: Y103LfsTer42
Effect: Frameshift
Impact: High Tumor Suppressor Impact
Mutation: Y107Ter
Effect: Frameshift
Impact: High Tumor Suppressor Impact
Lumin Data
RNASeq WES
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DAUDI

Tumor Indication: Lymphoid
Mutated Genes
APC
Mutation: V2561L
Effect: Missense
Impact: Probably Damaging
Mutation: A1679TfsTer4
Effect: Frameshift
Impact: High Tumor Suppressor Impact
Mutation: A1679VfsTer31
Effect: Frameshift
Impact: High Tumor Suppressor Impact
ARID1A
Mutation: L2061CfsTer75
Effect: Frameshift
Impact: High Tumor Suppressor Impact
Mutation: S1990TfsTer25
Effect: Frameshift
Impact: High Tumor Suppressor Impact
Mutation: W2049Ter
Effect: Stop-Gain
Impact: High Tumor Suppressor Impact
ATM
Mutation: A135LfsTer18
Effect: Frameshift
Impact: Pathogenic
Mutation: G138VfsTer4
Effect: Frameshift
Impact: High Tumor Suppressor Impact
Mutation: P453IfsTer33
Effect: Frameshift
Impact: High Tumor Suppressor Impact
ATR
Mutation: Splice variant
Effect: ESS Splice Varient
Impact: Cancer Driver
BRAF
Mutation: A145TfsTer13
Effect: Frameshift
Impact: High Oncogene Impact
Mutation: V144AfsTer39
Effect: Frameshift
Impact: High Oncogene Impact
CDK4
Mutation: Splice variant
Effect: Splice Donor Variant
Impact: High Oncogene Impact
FANCA
Mutation: S103Ter
Effect: Stop-Gain
Impact: Likely Pathogenic
FGFR2
Mutation: R111Ter
Effect: Frameshift
Impact: High Oncogene Impact
Mutation: S110VfsTer4
Effect: Frameshift
Impact: High Oncogene Impact
FLT4
Mutation: T618P
Effect: Missense
Impact: Possibly Damaging
IDH1
Mutation: A353LfsTer12
Effect: Frameshift
Impact: High Oncogene Impact
Mutation: F354AfsTer20
Effect: Frameshift
Impact: High Oncogene Impact
Mutation: H67Ter
Effect: Frameshift
Impact: High Oncogene Impact
LATS2
Mutation: P38QfsTer26
Effect: Frameshift
Impact: High Tumor Suppressor Impact
Mutation: P41GfsTer5
Effect: Frameshift
Impact: High Tumor Suppressor Impact
Mutation: V34RfsTer30
Effect: Frameshift
Impact: High Tumor Suppressor Impact
MSH6
Mutation: E1123RfsTer23
Effect: Frameshift
Impact: High Tumor Suppressor Impact
MYC
Mutation: L97PfsTer160
Effect: Frameshift
Impact: High Oncogene Impact
Mutation: P94RfsTer25
Effect: Frameshift
Impact: High Oncogene Impact
Mutation: P94TfsTer164
Effect: Frameshift
Impact: High Oncogene Impact
NOTCH1
Mutation: G2152AfsTer114
Effect: Frameshift
Impact: High Oncogene Impact
Mutation: Q2154PfsTer96
Effect: Frameshift
Impact: High Oncogene Impact
NTRK3
Mutation: L157SfsTer11
Effect: Frameshift
Impact: High Oncogene Impact
Mutation: L384GfsTer22
Effect: Frameshift
Impact: High Oncogene Impact
Mutation: P383AfsTer32
Effect: Frameshift
Impact: High Oncogene Impact
RET
Mutation: Q576RfsTer27
Effect: Frameshift
Impact: High Oncogene Impact
TP53
Mutation: G266E
Effect: Missense
Impact: Pathogenic
TSC1
Mutation: S525LfsTer6
Effect: Frameshift
Impact: High Tumor Suppressor Impact
Mutation: S526WfsTer10
Effect: Frameshift
Impact: High Tumor Suppressor Impact
TSC2
Mutation: Splice variant
Effect: ESS Splice Varient
Impact: Cancer Driver
Lumin Data
RNASeq WES
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Detroit 562

Tumor Indication: Pharyngeal
Mutated Genes
CDKN2A
Mutation: Splice variant
Effect: ESS Splice Varient
Impact: Cancer Driver
PIK3CA
Mutation: H1047R
Effect: Missense
Impact: Pathogenic
Mutation: H1047R
Effect: Missense
Impact: Cancer Driver
TP53
Mutation: R175H
Effect: Missense
Impact: Hotspot Mutation
Mutation: R175H
Effect: Missense
Impact: Cancer Driver
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DLD-1

Tumor Indication: Colorectal
Mutated Genes
APC
Mutation: R2166Ter
Effect: Stop-Gain
Impact: Pathogenic
Mutation: R727M
Effect: Missense
Impact: Probably Damaging
Mutation: I1417LfsTer2
Effect: Frameshift
Impact: High Tumor Suppressor Impact
ARID1B
Mutation: R1747Ter
Effect: Stop-Gain
Impact: Pathogenic
Mutation: G413Ter
Effect: Stop-Gain
Impact: High Tumor Suppressor Impact
ATR
Mutation: I1851V
Effect: Missense
Impact: Deleterious
AXL
Mutation: N677S
Effect: Missense
Impact: Deleterious
BRCA2
Mutation: C1200Ter
Effect: Frameshift
Impact: Pathogenic
Mutation: N1784TfsTer7
Effect: Frameshift
Impact: High Tumor Suppressor Impact
BRD4
Mutation: E1339G
Effect: Missense
Impact: Deleterious
Mutation: E451G
Effect: Missense
Impact: Deleterious
Mutation: Y432H
Effect: Missense
Impact: Deleterious
BTK
Mutation: K322E
Effect: Missense
Impact: Deleterious
CHEK2
Mutation: A247D
Effect: Missense
Impact: Deleterious
DNMT3A
Mutation: M761I
Effect: Missense
Impact: Probably Damaging
Mutation: R309C
Effect: Missense
Impact: Probably Damaging
ERBB3
Mutation: N126K
Effect: Missense
Impact: Deleterious
Mutation: P1142H
Effect: Missense
Impact: Deleterious
Mutation: R667H
Effect: Missense
Impact: Deleterious
ERBB4
Mutation: L369I
Effect: Missense
Impact: Probably Damaging
EZH2
Mutation: R418Q
Effect: Missense
Impact: Probably Damaging
FANCA
Mutation: E1178Ter
Effect: Stop-Gain
Impact: High Tumor Suppressor Impact
FANCD2
Mutation: R1273Q
Effect: Missense
Impact: Deleterious
FLT4
Mutation: N934D
Effect: Missense
Impact: Deleterious
IDH1
Mutation: G97D
Effect: Missense
Impact: Probably Damaging
KDR
Mutation: S925F
Effect: Missense
Impact: Deleterious
KEAP1
Mutation: A188T
Effect: Missense
Impact: Deleterious
KRAS
Mutation: G13D
Effect: Missense
Impact: Likely Pathogenic
LATS1
Mutation: T851I
Effect: Missense
Impact: Deleterious
LATS2
Mutation: E765D
Effect: Missense
Impact: Deleterious
Mutation: T1041I
Effect: Missense
Impact: Deleterious
MSH6
Mutation: D1171Ter
Effect: Frameshift
Impact: Pathogenic
Mutation: L290Ter
Effect: Frameshift
Impact: Pathogenic
PARP2
Mutation: H298Y
Effect: Missense
Impact: Deleterious
PIK3CA
Mutation: E545K
Effect: Missense
Impact: Deleterious
Mutation: D549N
Effect: Missense
Impact: Pathogenic
RET
Mutation: M980T
Effect: Missense, Splice Region Variant
Impact: Deleterious
TP53
Mutation: S241F
Effect: Missense
Impact: Likely Pathogenic
Mutation: Splice variant
Effect: Splice Acceptor Variant
Impact: High Tumor Suppressor Impact
TSC2
Mutation: V488M
Effect: Missense
Impact: Probably Damaging
Mutation: Y285H
Effect: Missense
Impact: Probably Damaging
Lumin Data
Proteomics
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DMS 114

Tumor Indication: Lung
Mutated Genes
AXL
Mutation: L255Ter
Effect: Frameshift
Impact: High Oncogene Impact
HGF
Mutation: T239I
Effect: Missense
Impact: Deleterious
TP53
Mutation: R213Ter
Effect: Stop-Gain
Impact: Pathogenic
Mutation: R213*
Effect: Nonsense
Impact: Cancer Driver
Lumin Data
RNASeq WES
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DU 145

Tumor Indication: Prostate
Mutated Genes
BRD4
Mutation: H1021IfsTer47
Effect: Frameshift
Impact: High Oncogene Impact
CDKN2A
Mutation: D84Y
Effect: Missense
Impact: Deleterious
Mutation: D84Y
Effect: Missense
Impact: Cancer Driver
CTNNB1
Mutation: A305G
Effect: Missense
Impact: Deleterious Low Confidence
HGF
Mutation: R630L
Effect: Missense
Impact: Deleterious
KDR
Mutation: C466F
Effect: Missense
Impact: Deleterious
MAPK3
Mutation: C271Y
Effect: Missense
Impact: Deleterious Low Confidence
MARK2
Mutation: R259P
Effect: Missense
Impact: Probably Damaging
Mutation: R259P
Effect: Missense
Impact: Cancer Driver
MLH1
Mutation: Splice variant
Effect: Splice Acceptor Variant
Impact: Likely Pathogenic
Mutation: Splice variant
Effect: ESS Splice Varient
Impact: Cancer Driver
MSH6
Mutation: S1067I
Effect: Missense
Impact: Deleterious
NOTCH2
Mutation: A1083SfsTer17
Effect: Frameshift
Impact: Pathogenic
Mutation: P365L
Effect: Missense
Impact: Possibly Damaging
Mutation: A1083fs*17
Effect: Frameshift
Impact: Cancer Driver
NTRK2
Mutation: K599N
Effect: Missense
Impact: Probably Damaging
NTRK3
Mutation: N262MfsTer7
Effect: Frameshift
Impact: High Oncogene Impact
RB1
Mutation: K715Ter
Effect: Stop-Gain
Impact: High Tumor Suppressor Impact
Mutation: K715*
Effect: Nonsense
Impact: Cancer Driver
RET
Mutation: L746M
Effect: Missense
Impact: Deleterious
Mutation: V804M
Effect: Missense
Impact: Likely Pathogenic
Mutation: V804M
Effect: Missense
Impact: Cancer Driver
STAT6
Mutation: Q281PfsTer92
Effect: Frameshift
Impact: High Oncogene Impact
STK11
Mutation: K178GfsTer86
Effect: Frameshift
Impact: High Tumor Suppressor Impact
Mutation: K178fs*86
Effect: Frameshift
Impact: Cancer Driver
TERT
Mutation: Splice variant
Effect: Splice Acceptor Variant
Impact: High Oncogene Impact
Mutation: Splice variant
Effect: ESS Splice Varient
Impact: Cancer Driver
TP53
Mutation: P223L
Effect: Missense
Impact: Deleterious
Mutation: V274F
Effect: Missense
Impact: Pathogenic
Mutation: P223L
Effect: Missense
Impact: Cancer Driver
Mutation: V274F
Effect: Missense
Impact: Cancer Driver
TSC1
Mutation: G1034C
Effect: Missense
Impact: Deleterious
Lumin Data
RNASeq WES
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FaDu

Tumor Indication: Head and Neck
Mutated Genes
CDKN2A
Mutation: Splice variant
Effect: ESS Splice Varient
Impact: Cancer Driver
Mutation: Splice variant
Effect: Splice Acceptor Variant
Impact: Likely Pathogenic
RAF1
Mutation: P614L
Effect: Missense
Impact: Probably Damaging
ROS1
Mutation: Y2108C
Effect: Missense
Impact: Deleterious
TP53
Mutation: Splice variant
Effect: ESS Splice Varient
Impact: Cancer Driver
Mutation: R248L
Effect: Missense
Impact: Likely Pathogenic
Mutation: Splice variant
Effect: Splice Acceptor Variant
Impact: Pathogenic
VHL
Mutation: M1I
Effect: Start-Loss
Impact: Cancer Driver
Mutation: M1?
Effect: Start-Loss
Impact: High Tumor Suppressor Impact
Lumin Data
Proteomics RNASeq WES
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GRANTA-519

Tumor Indication: Lymphoma
Mutated Genes
ATM
Mutation: Splice variant
Effect: ESS Splice
Impact: Cancer Driver
Mutation: R2832C
Effect: Missense
Impact: Cancer Driver
Lumin Data
Proteomics RNASeq WES
View on Lumin

HCT 116

Tumor Indication: Colorectal
Mutated Genes
ABL1
Mutation: Y257C
Effect: Missense
Impact: Probably Damaging
ARAF
Mutation: R255GfsTer37
Effect: Frameshift
Impact: High Oncogene Impact
ATM
Mutation: A1127V
Effect: Missense
Impact: Cancer Driver
AXL
Mutation: M589K
Effect: Missense
Impact: Deleterious
Mutation: P337LfsTer29
Effect: Frameshift
Impact: High Oncogene Impact
BRCA2
Mutation: I2675DfsTer6
Effect: Frameshift
Impact: Pathogenic
Mutation: I2675fs*6
Effect: Frameshift
Impact: Cancer Driver
CDKN2A
Mutation: E33SfsTer15
Effect: Frameshift
Impact: High Tumor Suppressor Impact
Mutation: R24SfsTer20
Effect: Frameshift
Impact: High Tumor Suppressor Impact
Mutation: E33fs*15
Effect: Frameshift
Impact: Cancer Driver
CHEK2
Mutation: L355P
Effect: Missense
Impact: Deleterious
CTNNB1
Mutation: S45del
Effect: Inframe Deletion
Impact: Pathogenic
Mutation: S45delS
Effect: Inframe
Impact: Cancer Driver
ERBB3
Mutation: Q261Ter
Effect: Stop-Gain
Impact: High Oncogene Impact
FANCA
Mutation: P615HfsTer25
Effect: Frameshift
Impact: High Tumor Suppressor Impact
Mutation: P615fs*25
Effect: Frameshift
Impact: Cancer Driver
FGFR2
Mutation: P582L
Effect: Missense
Impact: Deleterious Low Confidence
FLT3
Mutation: P986AfsTer27
Effect: Frameshift
Impact: High Oncogene Impact
FLT4
Mutation: S1046L
Effect: Missense
Impact: Deleterious
Mutation: Q423RfsTer70
Effect: Frameshift
Impact: High Oncogene Impact
Mutation: Q423fs*70
Effect: Frameshift
Impact: Cancer Driver
Mutation: S1046L
Effect: Missense
Impact: Cancer Driver
IDH1
Mutation: S261L
Effect: Missense
Impact: Possibly Damaging
KDM5A
Mutation: G1200DfsTer9
Effect: Frameshift
Impact: High Oncogene Impact
KRAS
Mutation: G13D
Effect: Missense
Impact: Likely Pathogenic
Mutation: G13D
Effect: Missense
Impact: Cancer Driver
LATS1
Mutation: P533LfsTer8
Effect: Frameshift
Impact: High Tumor Suppressor Impact
Mutation: P533fs*8
Effect: Frameshift
Impact: Cancer Driver
MERTK
Mutation: R722Ter
Effect: Stop-Gain
Impact: Pathogenic
MET
Mutation: L238YfsTer25
Effect: Frameshift
Impact: High Oncogene Impact
MLH1
Mutation: S252Ter
Effect: Stop-Gain
Impact: Pathogenic
Mutation: S252*
Effect: Nonsense
Impact: Cancer Driver
MSH6
Mutation: F1088LfsTer5
Effect: Frameshift
Impact: Likely Pathogenic
Mutation: F1088fs*5
Effect: Frameshift
Impact: Cancer Driver
NF1
Mutation: P388T
Effect: Missense
Impact: Probably Damaging
Mutation: I679fs*21
Effect: Frameshift
Impact: Cancer Driver
Mutation: P678fs*10
Effect: Frameshift
Impact: Cancer Driver
NOTCH1
Mutation: G115AfsTer8
Effect: Frameshift
Impact: High Oncogene Impact
NTRK3
Mutation: I837T
Effect: Missense
Impact: Probably Damaging
PIK3CA
Mutation: H1047R
Effect: Missense
Impact: Pathogenic
Mutation: H1047R
Effect: Missense
Impact: Cancer Driver
STAT6
Mutation: Q281PfsTer92
Effect: Frameshift
Impact: High Oncogene Impact
Lumin Data
RNASeq WES
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Hela

Tumor Indication: Cervical
Lumin Data
RNASeq WES
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Hep 3B

Tumor Indication: Hepatocellular Carcinoma
Mutated Genes
ARID1B
Mutation: G953S
Effect: Missense
Impact: Cancer Driver
JAK3
Mutation: P132T
Effect: Missense
Impact: Cancer Driver
MSH6
Mutation: Splice variant
Effect: ESS Splice Varient
Impact: Cancer Driver
NTRK1
Mutation: R444Q
Effect: Missense
Impact: Cancer Driver
RB1
Mutation: S576Ter
Effect: Stop-Gain
Impact: High Tumor Suppressor Impact
Mutation: S576*
Effect: Nonsense
Impact: Cancer Driver
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Hep G2

Tumor Indication: Hepatocellular Carcinoma
Mutated Genes
KDR
Mutation: Y357N
Effect: Missense
Impact: Deleterious
NF1
Mutation: Splice variant
Effect: Splice Donor Variant
Impact: High Tumor Suppressor Impact
NOTCH1
Mutation: H2125Q
Effect: Missense
Impact: Possibly Damaging
NRAS
Mutation: Q61L
Effect: Missense
Impact: Likely Pathogenic
Lumin Data
RNASeq WES
View on Lumin

HS 695T

Tumor Indication: Skin
Mutated Genes
ATM
Mutation: Q1825Ter
Effect: Stop-Gain
Impact: Pathogenic
Mutation: Q1825*
Effect: Nonsense
Impact: Cancer Driver
BRAF
Mutation: V600E
Effect: Missense
Impact: Pathogenic
Mutation: V600E
Effect: Missense
Impact: Cancer Driver
NF1
Mutation: Q959Ter
Effect: Stop-Gain
Impact: Pathogenic
Mutation: Q959*
Effect: Nonsense
Impact: Cancer Driver
PDGFRA
Mutation: I965N
Effect: Missense
Impact: Deleterious
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HT-1080

Tumor Indication: Sarcoma
Mutated Genes
IDH1
Mutation: R132C
Effect: Missense
Impact: Pathogenic
NRAS
Mutation: Q61K
Effect: Missense
Impact: Deleterious Low Confidence
Lumin Data
RNASeq WES
View on Lumin

HT-1376

Tumor Indication: Bladder
Mutated Genes
ARID1A
Mutation: p.S186fs*209
Effect: Frameshift
Impact: Cancer Driver
Mutation: p.S186RfsTer209
Effect: Frameshift Variant
Impact: Tumor Suppressor High Impact
RB1
Mutation: p.Q702*
Effect: Nonsense
Impact: Cancer Driver
TP53
Mutation: p.P250L
Effect: Missense
Impact: Cancer Driver
View on Lumin

HT-29

Tumor Indication: Colorectal
Mutated Genes
APC
Mutation: T1556fs*3
Effect: Frameshift
Impact: Cancer Driver
Mutation: E853Ter
Effect: Stop-Gain
Impact: Pathogenic
Mutation: T1556NfsTer3
Effect: Frameshift
Impact: Pathogenic
BRAF
Mutation: V600E
Effect: Missense
Impact: Pathogenic
PIK3CA
Mutation: P449T
Effect: Missense
Impact: Pathogenic
SMAD4
Mutation: Q311Ter
Effect: Stop-Gain
Impact: Pathogenic
TP53
Mutation: R273H
Effect: Missense
Impact: Pathogenic
Lumin Data
Proteomics RNASeq WES
View on Lumin

Huh-7

Tumor Indication: Liver
Mutated Genes
TP53
Mutation: p.Y220C
Effect: Missense Variant
Impact: Cancer Driver
View on Lumin

JEG-3

Tumor Indication: Uterine
Mutated Genes
CCNE1
Mutation: A303T
Effect: Missense
Impact: Deleterious
ERBB4
Mutation: L74H
Effect: Missense
Impact: Probably Damaging
LATS1
Mutation: Q645H
Effect: Missense
Impact: Deleterious
RET
Mutation: D1004Y
Effect: Missense
Impact: Deleterious
View on Lumin

JeKo-1

Tumor Indication: Lymphoma
Mutated Genes
ATR
Mutation: T1751A
Effect: Missense
Impact: Deleterious
ATRX
Mutation: R246C
Effect: Missense
Impact: Pathogenic
CHEK2
Mutation: V175A
Effect: Missense
Impact: Deleterious
RB1
Mutation: R621S
Effect: Missense
Impact: Cancer Driver
TP53
Mutation: P58fs*65
Effect: Frameshift
Impact: Cancer Driver
Mutation: P58QfsTer65
Effect: Frameshift
Impact: Pathogenic
Lumin Data
RNASeq WES
View on Lumin

JIMT-1

Tumor Indication: Breast
Mutated Genes
PIK3CA
Mutation: C420R
Effect: Missense
Impact: Likely Pathogenic
TP53
Mutation: R248W
Effect: Missense
Impact: Pathogenic
Lumin Data
Proteomics
View on Lumin

LNCaP clone FGC

Tumor Indication: Prostate
Mutated Genes
AR
Mutation: T878A
Effect: Missense
Impact: Pathogenic
Mutation: T878A
Effect: Missense
Impact: Cancer Driver
ARID1A
Mutation: G285EfsTer78
Effect: Frameshift
Impact: High Tumor Suppressor Impact
Mutation: G285fs*78
Effect: Frameshift
Impact: Cancer Driver
ARID1B
Mutation: E2287Ter
Effect: Stop-Gain
Impact: High Tumor Suppressor Impact
Mutation: E2204*
Effect: Nonsense
Impact: Cancer Driver
ATM
Mutation: Q912*
Effect: Nonsense
Impact: Cancer Driver
CDK4
Mutation: P110L
Effect: Missense
Impact: Deleterious
CHEK2
Mutation: T387N
Effect: Missense
Impact: Deleterious
ERBB4
Mutation: Q1126*
Effect: Nonsense
Impact: Cancer Driver
ESR1
Mutation: Splice variant
Effect: Splice Donor Variant
Impact: High Oncogene Impact
FLT4
Mutation: Y1091C
Effect: Missense
Impact: Deleterious
HGF
Mutation: E217K
Effect: Missense
Impact: Deleterious
JAK1
Mutation: K142RfsTer26
Effect: Frameshift
Impact: High Oncogene Impact
Mutation: L431VfsTer22
Effect: Frameshift
Impact: High Oncogene Impact
Mutation: K142fs*26
Effect: Frameshift
Impact: Cancer Driver
Mutation: L431fs*22
Effect: Frameshift
Impact: Cancer Driver
KDM5A
Mutation: G1200DfsTer9
Effect: Frameshift
Impact: High Oncogene Impact
KDR
Mutation: A1065T
Effect: Missense, Splice Region Variant
Impact: Deleterious
Mutation: A1065T
Effect: Missense
Impact: Cancer Driver
MYC
Mutation: N45S
Effect: Missense
Impact: Deleterious
NOTCH2
Mutation: Splice variant
Effect: Splice Acceptor Variant
Impact: High Oncogene Impact
Mutation: Splice variant
Effect: ESS Splice Varient
Impact: Cancer Driver
NTRK3
Mutation: E287Ter
Effect: Stop-Gain
Impact: High Oncogene Impact
PTEN
Mutation: K6RfsTer4
Effect: Frameshift
Impact: Pathogenic
Mutation: K6fs*4
Effect: Frameshift
Impact: Cancer Driver
RET
Mutation: I858T
Effect: Missense
Impact: Deleterious
Mutation: R77H
Effect: Missense
Impact: Cancer Driver
STAT6
Mutation: S531I
Effect: Missense
Impact: Deleterious
TERT
Mutation: R865C
Effect: Missense
Impact: Likely Pathogenic
TOP1
Mutation: A705S
Effect: Missense
Impact: Probably Damaging
TSC1
Mutation: G147W
Effect: Missense
Impact: Deleterious
Lumin Data
RNASeq WES
View on Lumin

LoVo

Tumor Indication: Bowel
Mutated Genes
ALK
Mutation: G1580V
Effect: Missense
Impact: Deleterious
APC
Mutation: M1431fs*42
Effect: Frameshift
Impact: Cancer Driver
Mutation: R1114Ter
Effect: Stop-Gain
Impact: Pathogenic
Mutation: M1431CfsTer42
Effect: Frameshift
Impact: Pathogenic
ARID1A
Mutation: F2141fs*59
Effect: Frameshift
Impact: Cancer Driver
Mutation: F2141SfsTer59
Effect: Frameshift
Impact: High Tumor Suppressor Impact
AXL
Mutation: R48W
Effect: Missense
Impact: Deleterious
CHEK2
Mutation: T389PfsTer25
Effect: Frameshift
Impact: Likely Pathogenic
DNMT3A
Mutation: R209H
Effect: Missense
Impact: Probably Damaging
FGFR3
Mutation: I532V
Effect: Missense
Impact: Probably Damaging
IDH1
Mutation: I5NfsTer13
Effect: Frameshift
Impact: High Oncogene Impact
KRAS
Mutation: G13D
Effect: Missense
Impact: Likely Pathogenic
LATS2
Mutation: P516L
Effect: Missense
Impact: Deleterious
MTOR
Mutation: Splice variant
Effect: Splice Acceptor Variant
Impact: High Oncogene Impact
NF1
Mutation: R1695Q
Effect: Missense
Impact: Possibly Damaging
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MIA PaCa-2

Tumor Indication: Pancreatic
Mutated Genes
AR
Mutation: G536R
Effect: Missense
Impact: Deleterious
ARID1A
Mutation: Q321Ter
Effect: Stop-Gain
Impact: High Tumor Suppressor Impact
KRAS
Mutation: G12C
Effect: Missense
Impact: Likely Pathogenic
MLH1
Mutation: T270I
Effect: Missense
Impact: Deleterious
TP53
Mutation: R248W
Effect: Missense
Impact: Pathogenic
Lumin Data
RNASeq WES
View on Lumin

MKN-45

Tumor Indication: Esophageal, Gastric
Mutated Genes
ARID1A
Mutation: Q321GfsTer70
Effect: Frameshift
Impact: High Tumor Suppressor Impact
TP53
Mutation: R110C
Effect: Missense
Impact: Cancer Driver
Mutation: R110C
Effect: Missense
Impact: Hotspot Mutation
Lumin Data
Proteomics RNASeq WES
View on Lumin

MM.1R

Tumor Indication: Lymphoid
Lumin Data
RNASeq WES
View on Lumin

MM.1S

Tumor Indication: Lymphoid
Mutated Genes
EGFR
Mutation: G917R
Effect: Missense
Impact: Probably Damaging
KRAS
Mutation: G12A
Effect: Missense
Impact: Cancer Driver
Mutation: G12A
Effect: Missense
Impact: Pathogenic
ROS1
Mutation: D1385Y
Effect: Missense
Impact: Deleterious
Lumin Data
RNASeq WES
View on Lumin

NCI-H1373

Tumor Indication: Lung
Mutated Genes
ATM
Mutation: E2943Ter
Effect: Stop-Gain
Impact: High Tumor Suppressor Impact
BTK
Mutation: K60M
Effect: Missense
Impact: Deleterious
Mutation: R82I
Effect: Missense
Impact: Possibly Damaging
CDKN2A
Mutation: C72Ter
Effect: Stop-Gain
Impact: High Tumor Suppressor Impact
KIT
Mutation: D876Y
Effect: Missense
Impact: Deleterious
KRAS
Mutation: G12C
Effect: Missense
Impact: Likely Pathogenic
NF1
Mutation: I1827M
Effect: Missense
Impact: Probably Damaging
PDGFRA
Mutation: Splice variant
Effect: Splice Acceptor Variant
Impact: High Oncogene Impact
TP53
Mutation: E339Ter
Effect: Stop-Gain
Impact: Pathogenic
Lumin Data
Proteomics RNASeq WES
View on Lumin

NCI-H460

Tumor Indication: Lung
Mutated Genes
KEAP1
Mutation: p.D236H
Effect: Missense
Impact: Cancer Driver
KRAS
Mutation: p.Q61H
Effect: Missense
Impact: Cancer Driver
MAP2K1
Mutation: p.Y134C
Effect: Missense Variant
Impact: Likely Pathogenic
PIK3CA
Mutation: p.E545K
Effect: Missense
Impact: Cancer Driver
STK11
Mutation: p.Q37*
Effect: Nonsense
Impact: Cancer Driver
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NCI-H82

Tumor Indication: Lung
Mutated Genes
NF1
Mutation: S331R
Effect: Missense
Impact: Possibly Damaging
RB1
Mutation: Splice variant
Effect: ESS Splice Varient
Impact: Cancer Driver
Mutation: Splice variant
Effect: Splice Acceptor Variant
Impact: High Tumor Suppressor Impact
View on Lumin

NCI-H929

Tumor Indication: Lymphoid
Mutated Genes
ATM
Mutation: E347K
Effect: Missense
Impact: Possibly Damaging
FGFR4
Mutation: Splice variant
Effect: Splice Acceptor Variant
Impact: High Oncogene Impact
NRAS
Mutation: G13D
Effect: Missense
Impact: Likely Pathogenic
Lumin Data
Proteomics RNASeq WES
View on Lumin

NCI-N87

Tumor Indication: Esophageal, Gastric
Mutated Genes
ERBB2
Mutation: L436V
Effect: Missense
Impact: Deleterious
TP53
Mutation: R248Q
Effect: Missense
Impact: Pathogenic
Lumin Data
Proteomics RNASeq WES
View on Lumin

OV-90

Tumor Indication: Ovarian
Mutated Genes
BRAF
Mutation: N486_P490delNVTAP
Effect: Inframe
Impact: Cancer Driver
CDKN2A
Mutation: A86D
Effect: Missense
Impact: Deleterious
FGFR4
Mutation: P352L
Effect: Missense, Splice Region Variant
Impact: Possibly Damaging
SMAD4
Mutation: R445Ter
Effect: Stop-Gain
Impact: Pathogenic
TP53
Mutation: S215R
Effect: Missense
Impact: Likely Pathogenic
Lumin Data
Proteomics RNASeq WES
View on Lumin

OVCAR-3

Tumor Indication: Ovarian
Mutated Genes
TP53
Mutation: R248Q
Effect: Missense
Impact: Cancer Driver
View on Lumin

PANC-1

Tumor Indication: Pancreatic
Mutated Genes
KRAS
Mutation: G12D
Effect: Missense
Impact: Likely Pathogenic
TP53
Mutation: R273H
Effect: Missense
Impact: Pathogenic
Lumin Data
Proteomics
View on Lumin

RAJI

Tumor Indication: Lymphoma
Mutated Genes
ERBB2
Mutation: R1048C
Effect: Missense
Impact: Cancer Driver
MYC
Mutation: T73I
Effect: Missense
Impact: Deleterious
Mutation: L193V
Effect: Missense
Impact: Deleterious
Mutation: E54D
Effect: Missense
Impact: Pathogenic
PTEN
Mutation: Splice variant
Effect: Splice Acceptor Variant
Impact: Pathogenic
TP53
Mutation: R213Q
Effect: Missense
Impact: Likely Pathogenic
Mutation: Y234H
Effect: Missense
Impact: Pathogenic
Lumin Data
RNASeq WES
View on Lumin

RKO

Tumor Indication: Colorectal
Mutated Genes
AKT3
Mutation: Q78K
Effect: Missense
Impact: Cancer Driver
ARID1A
Mutation: D1850fs*33
Effect: Frameshift
Impact: Cancer Driver
Mutation: P1115fs*46
Effect: Frameshift
Impact: Cancer Driver
Mutation: D1850TfsTer33
Effect: Frameshift
Impact: High Tumor Suppressor Impact
BRAF
Mutation: V600E
Effect: Missense
Impact: Pathogenic
BRCA1
Mutation: D435Y
Effect: Missense
Impact: Deleterious
BRCA2
Mutation: N1784fs*7
Effect: Frameshift
Impact: Cancer Driver
Mutation: N1784TfsTer7
Effect: Frameshift
Impact: High Tumor Suppressor Impact
BRD4
Mutation: E460G
Effect: Missense
Impact: Deleterious
Mutation: T295P
Effect: Missense
Impact: Pathogenic
CDK4
Mutation: Splice variant
Effect: Splice Acceptor Variant
Impact: High Oncogene Impact
EZH2
Mutation: E169K
Effect: Missense
Impact: Pathogenic
FANCA
Mutation: E345fs*63
Effect: Frameshift
Impact: Cancer Driver
Mutation: E345VfsTer63
Effect: Frameshift
Impact: High Tumor Suppressor Impact
IDH2
Mutation: G190D
Effect: Missense
Impact: Probably Damaging
LATS2
Mutation: D569G
Effect: Missense
Impact: Deleterious
MARK2
Mutation: A70T
Effect: Missense
Impact: Probably Damaging
MSH6
Mutation: Y1066fs*1
Effect: Frameshift
Impact: Cancer Driver
Mutation: Y1066Ter
Effect: Frameshift
Impact: High Tumor Suppressor Impact
NF1
Mutation: N2341fs*5
Effect: Frameshift
Impact: Cancer Driver
Mutation: Y628fs*3
Effect: Frameshift
Impact: Cancer Driver
Mutation: Y628TfsTer3
Effect: Frameshift
Impact: High Tumor Suppressor Impact
NF2
Mutation: P275fs*21
Effect: Frameshift
Impact: Cancer Driver
Mutation: P275HfsTer21
Effect: Frameshift
Impact: High Tumor Suppressor Impact
NTRK3
Mutation: L481V
Effect: Missense
Impact: Probably Damaging
PARP1
Mutation: K418SfsTer2
Effect: Frameshift
Impact: High Tumor Suppressor Impact
PIK3CA
Mutation: H1047R
Effect: Missense
Impact: Pathogenic
STAT3
Mutation: E616delE
Effect: Inframe
Impact: Cancer Driver
TSC2
Mutation: V805I
Effect: Missense
Impact: Possibly Damaging
Mutation: Y602H
Effect: Missense
Impact: Probably Damaging
View on Lumin

RPMI 8226

Tumor Indication: Lymphoid
Mutated Genes
EGFR
Mutation: T751I
Effect: Missense
Impact: Probably Damaging
ERBB4
Mutation: F247C
Effect: Missense, Splice Region Variant
Impact: Probably Damaging
JAK3
Mutation: P132T
Effect: Missense
Impact: Cancer Driver
KRAS
Mutation: G12A
Effect: Missense
Impact: Pathogenic
Mutation: G12A
Effect: Missense
Impact: Cancer Driver
TP53
Mutation: E285K
Effect: Missense
Impact: Likely Pathogenic
Mutation: E285K
Effect: Missense
Impact: Cancer Driver
View on Lumin

SHP-77

Tumor Indication: Lung
Mutated Genes
EGFR
Mutation: Q701R
Effect: Missense
Impact: Possibly Damaging
ERBB4
Mutation: G107V
Effect: Missense
Impact: Probably Damaging
EZH2
Mutation: S538L
Effect: Missense
Impact: Probably Damaging
KEAP1
Mutation: D294Y
Effect: Missense
Impact: Deleterious
KRAS
Mutation: G12V
Effect: Missense
Impact: Likely Pathogenic
TP53
Mutation: C176W
Effect: Missense
Impact: Likely Pathogenic
Lumin Data
Proteomics
View on Lumin

SK-MEL-5

Tumor Indication: Skin
Mutated Genes
APC
Mutation: L407F
Effect: Missense
Impact: Probably Damaging
BRAF
Mutation: V600E
Effect: Missense
Impact: Pathogenic
KDR
Mutation: S633F
Effect: Missense
Impact: Deleterious
Lumin Data
Proteomics RNASeq WES
View on Lumin

SK-N-MC

Tumor Indication: Sarcoma
Mutated Genes
RB1
Mutation: R698M
Effect: Missense
Impact: Cancer Driver
Mutation: R698S
Effect: Missense
Impact: Cancer Driver
Mutation: R698I
Effect: Missense
Impact: Deleterious
Lumin Data
Proteomics RNASeq WES
View on Lumin

SK-OV-3

Tumor Indication: Ovarian, Fallopian Tube
Mutated Genes
APC
Mutation: T1556fs*9
Effect: Frameshift
Impact: Cancer Driver
Mutation: T1556LfsTer9
Effect: Frameshift
Impact: Pathogenic
ARID1A
Mutation: Q586Ter
Effect: Stop-Gain
Impact: High Tumor Suppressor Impact
ATM
Mutation: Splice variant
Effect: ESS Splice Varient
Impact: Cancer Driver
Mutation: Splice variant
Effect: Splice Acceptor Variant
Impact: Likely Pathogenic
MLH1
Mutation: Y126SfsTer11
Effect: Frameshift
Impact: High Tumor Suppressor Impact
NF1
Mutation: G1702C
Effect: Missense
Impact: Probably Damaging
NOTCH2
Mutation: R1604fs*9
Effect: Frameshift
Impact: Cancer Driver
Mutation: R1604DfsTer9
Effect: Frameshift
Impact: High Oncogene Impact
PIK3CA
Mutation: H1047R
Effect: Missense
Impact: Pathogenic
TP53
Mutation: S90fs*33
Effect: Frameshift
Impact: Cancer Driver
Mutation: S90PfsTer33
Effect: Frameshift
Impact: Likely Pathogenic
Lumin Data
Proteomics RNASeq WES
View on Lumin

SK-UT-1

Tumor Indication: Uterine
Mutated Genes
ALK
Mutation: R1192Q
Effect: Missense
Impact: Deleterious
APC
Mutation: T1556fs*9
Effect: Frameshift
Impact: Cancer Driver
Mutation: Q1096Ter
Effect: Stop-Gain
Impact: Pathogenic
Mutation: T1556LfsTer9
Effect: Frameshift
Impact: Pathogenic
ARID1A
Mutation: P1326fs*155
Effect: Frameshift
Impact: Cancer Driver
Mutation: Y1324fs*157
Effect: Frameshift
Impact: Cancer Driver
Mutation: G276EfsTer87
Effect: Frameshift
Impact: High Tumor Suppressor Impact
ARID1B
Mutation: Q1899*
Effect: Nonsense
Impact: Cancer Driver
Mutation: Q2074*
Effect: Nonsense
Impact: Cancer Driver
Mutation: Q2157Ter
Effect: Stop-Gain
Impact: Pathogenic
EGFR
Mutation: A653PfsTer52
Effect: Frameshift
Impact: High Oncogene Impact
FANCD2
Mutation: G62R
Effect: Missense
Impact: Deleterious
MSH2
Mutation: T788fs*10
Effect: Frameshift
Impact: Cancer Driver
Mutation: T788SfsTer10
Effect: Frameshift
Impact: Likely Pathogenic
MTOR
Mutation: A41T
Effect: Missense
Impact: Probably Damaging
NOTCH1
Mutation: C227Y
Effect: Missense
Impact: Probably Damaging
NOTCH2
Mutation: R1787Q
Effect: Missense
Impact: Deleterious
PIK3CA
Mutation: R88Q
Effect: Missense
Impact: Pathogenic
PTEN
Mutation: N323fs*2
Effect: Frameshift
Impact: Cancer Driver
Mutation: T319fs*1
Effect: Frameshift
Impact: Cancer Driver
Mutation: N323KfsTer2
Effect: Frameshift
Impact: Likely Pathogenic
RB1
Mutation: V654fs*4
Effect: Frameshift
Impact: Cancer Driver
Mutation: V654CfsTer4
Effect: Frameshift
Impact: High Tumor Suppressor Impact
TP53
Mutation: R175H
Effect: Missense
Impact: Hotspot Mutation
Mutation: R248Q
Effect: Missense
Impact: Pathogenic
TSC2
Mutation: Q90Ter
Effect: Stop-Gain
Impact: Pathogenic
Lumin Data
Proteomics RNASeq WES
View on Lumin

SNU-5

Tumor Indication: Gastric
Mutated Genes
BRCA2
Mutation: E2292A
Effect: Missense
Impact: Deleterious
CDKN2A
Mutation: R80Ter
Effect: Stop-Gain
Impact: Hotspot Mutation
MSH6
Mutation: K1358fs*2
Effect: Frameshift
Impact: Cancer Driver
NOTCH1
Mutation: T617P
Effect: Missense
Impact: Probably Damaging
Mutation: G616A
Effect: Missense
Impact: Probably Damaging
NOTCH2
Mutation: N1027S
Effect: Missense
Impact: Deleterious
TP53
Mutation: Splice variant
Effect: ESS Splice Varient
Impact: Cancer Driver
Lumin Data
Proteomics RNASeq WES
View on Lumin

SU-DHL-2

Tumor Indication: Lymphoma
Mutated Genes
ARID1A
Mutation: p.G455R
Effect: Missense Variant
Impact: Likely Pathogenic
FLT4
Mutation: p.V160L
Effect: Missense Variant
Impact: Likely Pathogenic
MSH2
Mutation: N/A - splice site variant
Effect: Splice Acceptor Variant
Impact: Tumor Suppressor High Impact
NTRK3
Mutation: p.M803I
Effect: Missense Variant
Impact: Likely Pathogenic
SMAD4
Mutation: p.P130S
Effect: Missense Variant
Impact: Likely Pathogenic
TP53
Mutation: p.Y234S
Effect: Missense Variant
Impact: Hotspot Mutation
View on Lumin

SU-DHL-4

Tumor Indication: Lymphoma
Mutated Genes
EZH2
Mutation: Y646S
Effect: Missense
Impact: Likely Pathogenic
Mutation: Y666N
Effect: Missense
Impact: Possibly Damaging
TP53
Mutation: R273C
Effect: Missense
Impact: Deleterious
Lumin Data
Proteomics RNASeq WES
View on Lumin

SU-DHL-6

Tumor Indication: Lymphoma
Mutated Genes
ARID1A
Mutation: Q200Ter
Effect: Stop-Gain
Impact: High Tumor Suppressor Impact
EZH2
Mutation: Y646N
Effect: Missense
Impact: Likely Pathogenic
MTOR
Mutation: V169I
Effect: Missense, Splice Region Variant
Impact: Probably Damaging
TP53
Mutation: Splice variant
Effect: ESS Splice Varient
Impact: Cancer Driver
Mutation: Splice variant
Effect: Splice Acceptor Variant
Impact: Pathogenic
Mutation: Y234C
Effect: Missense
Impact: Pathogenic
Lumin Data
Proteomics RNASeq WES
View on Lumin

SU-DHL-8

Tumor Indication: Lymphoma
Mutated Genes
BRAF
Mutation: T599_V600insT
Effect: Inframe
Impact: Cancer Driver
Mutation: T599dup
Effect: Inframe Insertion
Impact: Pathogenic
MYC
Mutation: P72S
Effect: Missense
Impact: Pathogenic
TP53
Mutation: R249G
Effect: Missense
Impact: Likely Pathogenic
Mutation: Y234N
Effect: Missense
Impact: Pathogenic
Lumin Data
Proteomics RNASeq WES
View on Lumin

SW480

Tumor Indication: Colorectal
Mutated Genes
APC
Mutation: Q1338Ter
Effect: Stop-Gain
Impact: Pathogenic
ATM
Mutation: R2461P
Effect: Missense
Impact: Possibly Damaging
ERBB2
Mutation: E1229Ter
Effect: Stop-Gain
Impact: High Oncogene Impact
KRAS
Mutation: G12V
Effect: Missense
Impact: Likely Pathogenic
MERTK
Mutation: G590Ter
Effect: Stop-Gain
Impact: High Oncogene Impact
ROS1
Mutation: L931Q
Effect: Missense
Impact: Deleterious
Mutation: P1131L
Effect: Missense
Impact: Deleterious
TP53
Mutation: R273H
Effect: Missense
Impact: Pathogenic
Lumin Data
Proteomics RNASeq WES
View on Lumin

SW620

Tumor Indication: Colorectal
Mutated Genes
APC
Mutation: Q1338Ter
Effect: Stop-Gain
Impact: Pathogenic
Mutation: Q1338*
Effect: Nonsense
Impact: Cancer Driver
KRAS
Mutation: G12V
Effect: Missense
Impact: Likely Pathogenic
Mutation: G12V
Effect: Missense
Impact: Cancer Driver
SMAD4
Mutation: Splice variant
Effect: ESS Splice Varient
Impact: Cancer Driver
TP53
Mutation: R273H
Effect: Missense
Impact: Pathogenic
Mutation: P309S
Effect: Missense
Impact: Cancer Driver
Mutation: R273H
Effect: Missense
Impact: Cancer Driver
View on Lumin

THP-1

Tumor Indication: Leukemia
Mutated Genes
FANCD2
Mutation: Y1117F
Effect: Missense
Impact: Deleterious
NRAS
Mutation: G12D
Effect: Missense
Impact: Likely Pathogenic
TP53
Mutation: R174fs*3
Effect: Frameshift
Impact: Cancer Driver
Mutation: R174LfsTer3
Effect: Frameshift
Impact: High Tumor Suppressor Impact
Lumin Data
RNASeq WES
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U-87 MG

Tumor Indication: Glioblastoma
Mutated Genes
NF1
Mutation: F1247IfsTer18
Effect: Frameshift
Impact: Pathogenic
Mutation: K1444M
Effect: Missense, Splice Region Variant
Impact: Probably Damaging
Mutation: F1247fs*18
Effect: Frameshift
Impact: Cancer Driver
PTEN
Mutation: Splice variant
Effect: Splice Donor Variant
Impact: Pathogenic
Mutation: Splice variant
Effect: ESS Splice Varient
Impact: Cancer Driver
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UM-UC-14

Tumor Indication: Bladder
Mutated Genes
FGFR3
Mutation: S249C
Effect: Missense
Impact: Likely Pathogenic
PIK3CA
Mutation: E418K
Effect: Missense, Splice Region Variant
Impact: Likely Pathogenic
TP53
Mutation: R280T
Effect: Missense
Impact: Likely Pathogenic
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VCaP

Tumor Indication: Prostate
Mutated Genes
MSH6
Mutation: p.F1088fs*5
Effect: Frameshift
Impact: Cancer Driver
Mutation: p.F1088LfsTer5
Effect: Frameshift Variant
Impact: Likely Pathogenic
TP53
Mutation: p.R248W
Effect: Missense
Impact: Cancer Driver
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Mutation Data Sources
Expression Data Sources

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