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Read Champions' peer-reviewed publications by our experts and our partners.
Autologous TIL Platform
Clinical Flow Cytometry
Hematological Malignancies
Humanized Models
Lumin Acuity
Solid Tumor PDX Models

The Journal of Clinical Investigation - Antitumor activity of AZD0754, a dnTGFβRII-armored, STEAP2-targeted CAR-T cell therapy, in prostate cancer - 2023

Cancer Research - The Next-Generation Oral Selective Estrogen Receptor Degrader Camizestrant (AZD9833) Suppresses ER+ Breast Cancer Growth and Overcomes Endocrine and CDK4/6 Inhibitor Resistance - 2023

Cancer Research Communications - PRMT5 Inhibitors Regulate DNA Damage Repair Pathways in Cancer Cells and Imrpove Response to PARP Inhibition and Chemotherapies - 2023

Journal for ImmunoTherapy of Cancer - INBRX-120, a CD8α-targeted detuned IL-2 that selectively expands and activates tumoricidal effector cells for safe and durable in vivo responses - 2023

Molecular Cancer Therapeutics - SGN-CD228A is an investigational CD228-directed antibody-drug conjugate with potent antitumor activity across a wide spectrum of preclinical solid tumor models - 2023

Cancer Discovery - Zenocutuzumab, a HER2xHer3 Bispecific Antibody, Is Effective Therapy for Tumors Driven by NRG1 Gene Rearrangements - 2022

Molecular Cancer Therapeutics - DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-based Antibody-Drug Conjugate Targeting B7-H3 Exerts Potent Antitumor Activities in Preclinical Models - 2022

Molecular Cancer Therapeutics - Preclinical Development of ADCT-601, a Novel Pyrrolobenzodiazepine Dimer-based Antibody-drug Conjugate Targeting AXL-expressing Cancers - 2022

Journal of Medicinal Chemistry - Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer - 2021

Nature Communications - Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease - 2021

Cancer Cell - Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor - 2021

Clinical Cancer Research - The PSMA Targeting Half-Life Extended BiTE® Therapy AMG 160 Has Potent Antitumor Activity in Preclinical Models of Metastatic Castration-Resistant Prostate Cancer - 2021

Advanced Science News - Focal Adhesion Kinase (FAK) Inhibition Synergizes with KRAS G12C Inhibitors in Treating Cancer through the Regulation of the FAK–YAP Signaling - 2021

American Association for Cancer Research - Datopotamab Deruxtecan, a Novel TROP2-directed Antibody–drug Conjugate, Demonstrates Potent Antitumor Activity by Efficient Drug Delivery to Tumor Cells - 2021

BMC Cancer - ABBV-176, a PRLR Antibody Drug Conjugate with a Potent DNA-Damaging PBD Cytotoxin and Enhanced Activity with PARP Inhibition - 2021

American Association for Cancer Research - 3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer - 2021

Molecular Cancer Therapeutics - The Dolaflexin-based Antibody-Drug Conjugate XMT-1536 Targets the Solid Tumor Lineage Antigen SLC34A2/NaPi2b - 2021

British Journal of Cancer - SLFN11 informs on standard of care and novel treatments in a wide range of cancer models - 2020

Clinical Cancer Research - OMTX705, a Novel FAP-Targeting ADC Demonstrates Activity in Chemotherapy and Pembrolizumab-Resistant Solid Tumor Models - 2020

Cell - Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids - 2020

Molecular Cancer Therapeutics - Preclinical Activity of HER2-Selective Tyrosine Kinase Inhibitor Tucatinib as a Single Agent or in Combination with Trastuzumab or Docetaxel in Solid Tumor Models - 2020

Molecular Cancer Therapeutics - ERK Inhibitor LY3214996 Targets ERK Pathway–Driven Cancers: A Therapeutic Approach Toward Precision Medicine - 2020

Cells - Alternative Splicing of RAD6B and Not RAD6A Is Selectively Increased in Melanoma: Identification and Functional Characterization - 2019

Oncotarget - Volasertib preclinical activity in high-risk hepatoblastoma - 2019

Sci Signal - The HDAC3-SMARCA4-miR27a axis promotes expression of the PAX3:FOXO1 fusion oncogene in rhabdomyosarcoma - 2019

Breast Cancer Research - Elacestrant (RAD1901) exhibits anti-tumor activity in multiple ER+ breast cancer models resistant to CDK4/6 inhibitors - 2019

Oncogene - Combined PARP and ATR inhibition potentiates genome instability and cell death in ATM-deficient cancer cells - 2019

Nature Communications - AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity - 2019

Scientific Reports- Targeting CLDN18.2 by CD3 Bispecific and ADC Modalities for the Treatments of Gastric and Pancreatic Cancer - 2019

Nature Communications - The new-generation selective ROS1/NTRK inhibitor DS-6051b overcomes crizotinib resistant ROS1-G2032R mutation in preclinical models - 2019

Cancer Research - PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models - 2017

Annals of Oncology - Patient-derived xenografts effectively capture responses to oncology therapy in a heterogeneous cohort of patients with solid tumors - 2017

British Journal of Cancer - Comparative mutational landscape analysis of patient-derived tumour xenografts - 2017

Nature Communications - CX-5461 is a DNA G-Quadruplex Stabilizer with Selective Lethality in BRCA1/2 Deficient Tumours - 2017