Syngeneic mouse models are preclinical in vivo models used to evaluate therapeutic candidates in mice with intact immune system. Humanized mouse models support the engraftment of many functional components of the human immune system. This Quick Guide gives a comparison of the two models and weighs the benefits and challenges of these models for oncology research.
Humanized mouse models are models that support the engraftment of many functional components of the human immune system. These mouse models have various human immune cells engrafted and can be used to evaluate therapeutic candidates in a variety of human diseases. Read our Humanized Mouse Model Platform fact sheet to learn more about this platform.
Mouse models have been the workhorses of preclinical immuno-oncology (IO) research, and advances in mouse model development have expanded to applications for nearly all types of solid tumors and hematological malignancies. Here we highlight features of syngeneic and humanized mouse models and define which models are most relevant to different phases of preclinical IO research.
