What Makes This Screen Unique
Clinically Relevant Models
26 primary AML models engrafted in severely immunodeficient mice, preserving patient biology.
Pretreated PDX Models
Includes models pretreated with Gilteritinib, Mylotarg, experimental FLT3 inhibitors, anti-CD33 ADCs, and stem cell transplants.
Multi-omic Characterization
Full model characterization available in Lumin: clinical data, WES, RNAseq, and standard-of-care assessments.
Terminal Flow Cytometry
Analysis of peripheral blood and bone marrow (CD3, CD33, CD34, CD38, mCD45, hCD45, CD117, CD123, Viability Dye).
Optional Endpoint Analysis
Plasma-based Luminex.
Collaborative Benchmarking Arm (Shared SoC)
Clients enrolling in the screen can access cost-shared reference arms to benchmark therapeutic responses while reducing investment.
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5-Aza: CTG-2227, CTG-2235, CTG-2236, CTG-2239, CTG-2457, CTG-2700, CTG-2702, CTG-3438, 3440
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Cytarabine: CTG-2240
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Gilteritinib: CTG-2226, CTG-2232, CTG-2233, CTG-2237, CTG-2699, CTG-2704, CTG-3949, CTG-3950, CTG-4130, CTG-4196
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Venetoclax: CTG-2228, CTG-2358, CTG-3931, CTG-4052, CTG-4053, CTG-4128
Collaborative Benchmarking Arm (Shared SoC)
Clients enrolling in the screen can access cost-shared reference arms to benchmark therapeutic responses while reducing investment.
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5-Aza: CTG-2227, CTG-2235, CTG-2236, CTG-2239, CTG-2457, CTG-2700, CTG-2702, CTG-3438, 3440
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Cytarabine: CTG-2240
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Gilteritinib: CTG-2226, CTG-2232, CTG-2233, CTG-2237, CTG-2699, CTG-2704, CTG-3949, CTG-3950, CTG-4130, CTG-4196
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Venetoclax: CTG-2228, CTG-2358, CTG-3931, CTG-4052, CTG-4053, CTG-4128
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Model ID
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Test Agents
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|---|---|
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CTG-2226
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N/A
|
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CTG-2227
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Venetoclax, Gilteritinib, 5-Azacitidine + Venetoclax, Ivosidenib
|
|
CTG-2228
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Gilteritinib
|
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CTG-2232
|
N/A
|
|
CTG-2233
|
N/A
|
|
CTG-2235
|
Gilteritinib, Venetoclax, Tipifarnib
|
|
CTG-2236
|
Venetoclax, Cytarabine, Gilteritinib
|
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CTG-2237
|
Venetoclax
|
|
CTG-2239
|
Venetoclax, Tipifarnib, Gilteritinib, 5-Azacitidine + Venetoclax
|
|
CTG-2240
|
Venetoclax, Gilteritinib, Tipifarnib
|
|
CTG-2358
|
N/A
|
|
CTG-2457
|
Venetoclax, Gilteritinib, 5-Azacitidine + Venetoclax
|
|
CTG-2699
|
N/A
|
|
CTG-2700
|
Venetoclax
|
|
CTG-2702
|
Venetoclax
|
|
CTG-2704
|
Venetoclax
|
|
CTG-3438
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Venetoclax, Gilteritinib
|
|
CTG-3440
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Venetoclax, Gilteritinib, Tipifarnib
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|
CTG-3931
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N/A
|
|
CTG-3949
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N/A
|
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CTG-3950
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5-Azacitidine + Venetoclax
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|
CTG-4052
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N/A
|
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CTG-4053
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N/A
|
|
CTG-4128
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N/A
|
|
CTG-4130
|
N/A
|
|
CTG-4196
|
N/A
|