Services
With the most up-to-date and relevant bank of preclinical research models mirroring clinical trial patient populations, a large portfolio of novel proprietary platforms, and validated clinical specialty testing expertise, Champions is the ideal partner to deliver success and accelerate your drug development process.
![In Vivo Modeling](https://www.championsoncology.com/hs-fs/hubfs/9.jpg?width=1200&height=803&name=9.jpg)
In Vivo Modeling
Champions' in vivo testing solutions include a range of preclinical models and services for the preclinical assessment of novel anticancer agents across all therapeutic modalities, including cell therapy and immune-oncology agents. Champions offers:
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The most clinically annotated, molecularly-characterized bank of over 1,400 solid tumor and hematological models
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A growing bank of over 100 multi-omic characterized cell line-derived xenograft mouse models
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Characterized syngeneic and humanized mouse models for testing innovative immune-oncology therapeutics across multiple mechanisms of action
![Platforms_03](https://www.championsoncology.com/hs-fs/hubfs/Website%202023/Platforms_03.jpg?width=1200&height=628&name=Platforms_03.jpg)
SOLID TUMOR PDX MODELS
Over 1,400 clinically relevant TumorGraft® models with correlation to clinical outcomes
![Platforms_02](https://www.championsoncology.com/hs-fs/hubfs/Website%202023/Platforms_02.jpg?width=1200&height=628&name=Platforms_02.jpg)
HEMATOLOGICAL MODELS
A unique collection of primary never-passaged patient samples, accurately mirroring the heterogeneity of hematologic malignancies
![Platforms_01](https://www.championsoncology.com/hs-fs/hubfs/Website%202023/Platforms_01.jpg?width=1200&height=628&name=Platforms_01.jpg)
SYNGENEIC MODELS
A collection of murine models across multiple indications, with a complete and functional mouse immune system
![Platforms_05](https://www.championsoncology.com/hs-fs/hubfs/Website%202023/Platforms_05.jpg?width=1200&height=628&name=Platforms_05.jpg)
CDX MODELS
Over 100 cell-line derived xenograft mouse models to determine the efficacy of therapeutics
![Platforms_04](https://www.championsoncology.com/hs-fs/hubfs/Website%202023/Platforms_04.jpg?width=1200&height=628&name=Platforms_04.jpg)
HUMANIZED MODELS
A diverse portfolio of Champions' ImmunoGraft® to assess the effect of therapeutics on functional components of the human immune system
Ex Vivo Proprietary Platforms
Champions' ex vivo proprietary platforms are developed by expert R&D scientists to deliver insights and solve complex preclinical industry issues. These platforms are:
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Novel, high-throughput screening platforms to deliver insights and derisk preclinical programs
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Unique assays to assess mechanisms including cytotoxicity, proliferation, and infiltration
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Coupled with multiple readouts to validate targets or screen various cancer indications
![Ex Vivo Proprietary Platforms](https://www.championsoncology.com/hs-fs/hubfs/7.jpg?width=1200&height=803&name=7.jpg)
![Platforms_09](https://www.championsoncology.com/hs-fs/hubfs/Website%202023/Platforms_09.jpg?width=1200&height=628&name=Platforms_09.jpg)
HEMATOLOGICAL VITROSCREEN
Test therapeutics in over 80 highly characterized primary, never-passaged hematological models from AML, ALL, CLL, MCL, and MM patients
![Platforms_010](https://www.championsoncology.com/hs-fs/hubfs/Website%202023/Platforms_010.jpg?width=1200&height=628&name=Platforms_010.jpg)
TUMORGRAFT3D PLATFORM
Evaluate therapeutic efficacy in Champions' matrix-free, multiclonal 3D ex-vivo culture established from superior PDX models
![Platforms_08](https://www.championsoncology.com/hs-fs/hubfs/Website%202023/Platforms_08.jpg?width=1200&height=628&name=Platforms_08.jpg)
CO-CULTURE ASSAYS
Assess the effect therapeutic agents have on cancer cells and the immune system in the tumor microenvironment
![ScientistsInLab](https://www.championsoncology.com/hs-fs/hubfs/8.jpg?width=1200&height=803&name=8.jpg)
Clinical Specialty Testing
Champions is a clinical specialty testing lab offering high-complexity flow cytometry, plate-based assays, immunohistochemistry, and next-generation sequencing GCLP-compliant platforms. Champions operates at the highest standard of scientific excellence to provide superior results for each patient sample arriving onsite. As your clinical partner, Champions offers:
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Unrivaled expertise in study design and execution, sample logistics and processing, and data analysis of clinical samples
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Validated and fully customizable assays and collection kits for each analysis
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Optimum flexibility and operational readiness in each clinical assay and sample type to help you accomplish more with each test
![Platforms_016](https://www.championsoncology.com/hs-fs/hubfs/Website%202023/Platforms_016.jpg?width=1200&height=628&name=Platforms_016.jpg)
![Platforms_015](https://www.championsoncology.com/hs-fs/hubfs/Website%202023/Platforms_015.jpg?width=1200&height=628&name=Platforms_015.jpg)
HIGH COMPLEXITY FLOW CYTOMETRY
High-quality, complex computational results with the ability to interrogate up to 30 parameters on each individual cell simultaneously within each patient sample.
![Platforms_012](https://www.championsoncology.com/hs-fs/hubfs/Website%202023/Platforms_012.jpg?width=1200&height=628&name=Platforms_012.jpg)
LUMINEX & ELISA
Assess secreted protein levels longitudinally in clinical trials by mutiplex panel Luminex or custom-developed ELISA.
![Platforms_013](https://www.championsoncology.com/hs-fs/hubfs/Website%202023/Platforms_013.jpg?width=1200&height=628&name=Platforms_013.jpg)
HISTOLOGY & IMMUNOHISTOCHEMISTRY
Evaluate target expression and assess morphological changes within patient tissues of interest.
![Platforms_014](https://www.championsoncology.com/hs-fs/hubfs/Website%202023/Platforms_014.jpg?width=1200&height=628&name=Platforms_014.jpg)
NEXT GENERATION SEQUENCING
Determine patient segmentation and personalized medicine approaches based on bioinformatic and computational insights.
![Platforms_011](https://www.championsoncology.com/hs-fs/hubfs/Website%202023/Platforms_011.jpg?width=1200&height=628&name=Platforms_011.jpg)
SAMPLE COLLECTION KITS & LOGISTICS
Tube and reagent types are customizable and streamlined to ensure collection kits are delivered to each clinical site prior to SIV.