With the most up-to-date and relevant bank of preclinical research models mirroring clinical trial patient populations, a large portfolio of novel proprietary platforms, and validated clinical specialty testing expertise, Champions is the ideal partner to deliver success and accelerate your drug development process.
In Vivo Modeling
Champions' in vivo testing solutions include a range of preclinical models and services for the preclinical assessment of novel anticancer agents across all therapeutic modalities, including cell therapy and immune-oncology agents. Champions offers:
The most clinically annotated, molecularly-characterized bank of over 1,400 solid tumor and hematological models
A growing bank of over 100 multi-omic characterized cell line-derived xenograft mouse models
Characterized syngeneic and humanized mouse models for testing innovative immune-oncology therapeutics across multiple mechanisms of action
Over 1,400 clinically relevant TumorGraft® models with correlation to clinical outcomes
A unique collection of primary never-passaged patient samples, accurately mirroring the heterogeneity of hematologic malignancies
A collection of murine models across multiple indications, with a complete and functional mouse immune system
Over 100 cell-line derived xenograft mouse models to determine the efficacy of therapeutics
A diverse portfolio of Champions' ImmunoGraft® to assess the effect of therapeutics on functional components of the human immune system
Ex Vivo Proprietary Platforms
Champions' ex vivo proprietary platforms are developed by expert R&D scientists to deliver insights and solve complex preclinical industry issues. These platforms are:
Novel, high-throughput screening platforms to deliver insights and derisk preclinical programs
Unique assays to assess mechanisms including cytotoxicity, proliferation, and infiltration
Coupled with multiple readouts to validate targets or screen various cancer indications
Enable screening of cancer cell lines across all tumor indications for target validation and indication selection
Test therapeutics in over 80 highly characterized primary, never-passaged hematological models from AML, ALL, CLL, MCL, and MM patients
Evaluate therapeutic efficacy in Champions' matrix-free, multiclonal 3D ex-vivo culture established from superior PDX models
Assess the effect therapeutic agents have on cancer cells and the immune system in the tumor microenvironment
Clinical Specialty Testing
Champions is a clinical specialty testing lab offering high-complexity flow cytometry, plate-based assays, immunohistochemistry, and next-generation sequencing GCLP-compliant platforms. Champions operates at the highest standard of scientific excellence to provide superior results for each patient sample arriving onsite. As your clinical partner, Champions offers:
Unrivaled expertise in study design and execution, sample logistics and processing, and data analysis of clinical samples
Validated and fully customizable assays and collection kits for each analysis
Optimum flexibility and operational readiness in each clinical assay and sample type to help you accomplish more with each test
High-quality, complex computational results with the ability to interrogate up to 30 parameters on each individual cell simultaneously within each patient sample.
Assess secreted protein levels longitudinally in clinical trials by mutiplex panel Luminex or custom-developed ELISA.
Evaluate target expression and assess morphological changes within patient tissues of interest.
Determine patient segmentation and personalized medicine approaches based on bioinformatic and computational insights.
Tube and reagent types are customizable and streamlined to ensure collection kits are delivered to each clinical site prior to SIV.