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Pretreated PDX Models

Built for Tomorrow’s Therapies. Proven in Today’s Resistance.

Not All PDX Banks Are Created Equal

In a world where no cancer patient is truly treatment-naïve, why are most preclinical models? At Champions Oncology, we offer the largest and most clinically aligned bank of PDX models from pretreated patients in the industry, purpose-built to help you uncover resistance mechanisms, design next-line therapies, and accelerate clinical translation. Our models aren’t abstract avatars, they reflect the full clinical journey, including prior treatments, mutation status, and resistance evolution.

Clinically Relevant Models

The largest living bank of pretreated PDX models, mirroring today's clinical trial population

Pretreated PDX Models

Established from cancer patients treated with the latest generation therapies

Multi-omic Characterization

Extensive clinical annotations coupled with multi-omic datasets and in vivo responses 

Industry's Most Extensive Collection of Biologically Relevant, Pretreated PDX Tumor Models

  • 700+ pretreated models across 53 cancer types
  • 80% of pretreated models are from advanced/metastatic tumors
  • Unique Model Cohorts: EGFRi, PARPi, KRASi, CDKi, BTKi, MEKi, METi, mTORi, CSF1Ri, BETi, CPi, RTKi and many more

Pretreated PDX Model Indications & Modalities

Tumor Types

Available Curated Pretreated Model Cohorts

Breast Cancer Models:
  • HER2i Pretreated
  • CDK4/6i Pretreated ER+
Prostate Cancer Models:
  • Androgen Deprivation Therapy Resistant
Multi-Indication Models:
  • Osimertinib Pretreated EGFRm Models
  • Immune Therapy Pretreated Models
  • Immune Therapy Pretreated Resistant Models
  • PARPi Pretreated Models
  • Aromatase Inhibitor Resistant Models
  • Checkpoint Inhibitor (CPi) Immunotherapy Pretreated Models
  • Checkpoint Inhibitor (CPi) Immunotherapy Pretreated Resistant Models

Unlock Deeper Insights with Pretreated PDX Models

Go beyond first-line testing. Our pretreated PDX models give you the power to simulate real-world resistance, explore next-line therapies, and make data-driven decisions earlier in development. Whether you're validating a target, de-risking a clinical strategy, or identifying biomarkers of response, these models offer a translationally relevant platform built on real patient journeys.

  • Interrogate resistance mechanisms in tumors that have progressed after standard-of-care treatment.

  • Test the efficacy of novel agents in late-line settings where clinical need is greatest.

  • Design rational combinations that overcome resistance and deliver additive or synergistic effects.

  • Validate predictive biomarkers in a biologically intact, treatment-exposed setting.

  • Refine indication selection and trial design based on real-world therapeutic context.

"Champions Oncology’s pretreated PDX models have been a critical asset in our research. Their models provided us with invaluable insights into drug resistance and efficacy, enhancing our therapeutic development strategies."

___________________________________________________

Sr. Director, Biotech Company

"The detailed representation of prior treatment exposure in these models has been crucial for evaluating new therapies and developing effective strategies for overcoming resistance."

___________________________________________________

Head of Preclinical Research, Pharmaceutical Company

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about the most diverse, clinically relevant
tumor bank in the industry. 

Frequently Asked Questions

What are Pretreated PDX models ?
Pretreated PDX (Patient-Derived Xenograft) models are advanced research tools created by implanting human tumor tissue—previously exposed to specific cancer therapies and establishing them in animal models. This process allows researchers to study how tumors that have already been treated with drugs behave and evolve, including their mechanisms of resistance to those treatments. By mimicking real-world patient scenarios, pretreated PDX models offer valuable insights into the efficacy and resistance patterns of new anticancer therapies, enhancing the development of more effective treatments and minimizing risks in clinical trials.
What are the advantages of Champions' pretreated PDX models ?

Evaluating novel cancer therapies using Champion's biobank of pretreated PDX models offers several benefits, including:

Study Drug Resistance Mechanisms: A robust bank of 700+ pretreated models to investigate how tumors develop resistance to current treatments and identify new targets or strategies to counteract this resistance.

Evaluate Therapeutic Efficacy: Evaluate therapeutic efficacy of your novel therapies by testing them on a bank of pretreated models exposed to the latest therapies such as small molecule inhibitors, chemotherapy, antibodies, immunotherapeutics, and more.

Optimizing your pipeline and discovering new targets: Using pretreated PDX models helps optimize your test agents by understanding molecular interactions between the current line of treatments and cancers and identifying new drug targets, paving the way for more effective second- and third-line therapies.

Reducing Drug Development Costs: Utilizing pretreated PDX models in early drug testing can lower cancer drug development expenses by eliminating ineffective compounds before advancing to costly human clinical trials.

How do I find the most suitable pretreated PDX model for my research ?

You can access Champions’ database for model selection in Lumin:

Navigate to Lumin.bio and request access to Lumin Analytics.

There, you can use Model Select to search our database filtering for the tumor type and pretreatment of your need. You can also filter for in vivo response, molecular characteristics, and patient profile, to make your model selection the most precise and your studies the most successful. 

What defines a 'pretreated' model at Champions?

Tumors are collected after exposure to prior therapy,  most with multi-line treatment history and matched molecular data.

Can I access the model catalog before signing a contract?

Yes. Through Lumin, we provide transparent model summaries, filterable by indication, mutation, therapy, and resistance profile.

Do you support model customization or combo design?

Absolutely. Our team works alongside your scientists to tailor cohort selection and treatment regimens.

How is a pretreated PDX model different from a standard PDX model?

A pretreated PDX model is established from tumor tissue collected after a patient has received one or more lines of therapy. These models reflect resistance phenotypes and molecular adaptations that occur in response to treatment—offering greater translational relevance for drug development.

What types of therapies have your pretreated models been exposed to?

Our models span a wide range of modern therapies, including:

  • Small molecule inhibitors (EGFRi, KRASi, CDK4/6i, PARPi, MEKi, BETi, mTORi, etc.)
  • Biologics (trastuzumab, ADCs, bispecific antibodies)
  • Immune checkpoint inhibitors (anti-PD-1, anti-CTLA-4)
  • Hormonal therapies and chemotherapy
  • Experimental agents under clinical investigation
Can pretreated models mimic multi-line resistance patterns?

Yes. Many of our models are derived from patients with multiple prior lines of therapy, allowing you to simulate 2nd-line, 3rd-line, or even salvage settings. These models can be especially valuable for combination therapy design, resensitization studies, and late-line response prediction.

Are pretreated PDX models suitable for testing ADCs and immunotherapies?

Absolutely. We have ADC-exposed cohorts, IO-pretreated models, and immune-resistant tumors. These are ideal for evaluating payload efficacy, tumor penetration, re-sensitization strategies, and biomarker-guided combinations.

Can I use these models for biomarker discovery or validation?

Yes. All models come with multi-omic datasets, including mutation/CNV data, RNA expression, and in vivo response. This allows you to correlate biomarkers with therapeutic outcomes and refine patient selection strategies.

Do you have pretreated models for radiopharmaceutical testing?

Yes. Our models have been successfully used to evaluate radiolabeled compounds, particularly in treatment-resistant settings where standard therapies have failed. We can integrate imaging endpoints, biodistribution, and efficacy into study design.

How can I identify the right pretreated models for my study?

Use Lumin, our interactive analytics and model selection platform. Filter by tumor type, prior therapy, mutation status, biomarker expression, or resistance profile. If you prefer a collaborative approach, our scientists will work with you to define and recommend a customized cohort.

Can I see example model profiles before initiating a study?

Yes. Upon request or via Lumin, you’ll receive model summaries including:

  • Clinical treatment history
  • Tumor histology and site
  • Molecular profile
  • Prior in vivo response data (where available)
What if I can’t find a model that fits my target profile?

We may have models in expansion or in pre-qualification stages. If needed, we can also discuss custom model development or cohort enrichment strategies. Reach out to our scientific team to explore options.

How quickly can a study start using a pretreated model?

Most studies using pre-characterized models can start within 10–14 days depending on cohort size, treatment arms, and availability.

Are your models orthotopic, subcutaneous, or both?

Most pretreated models are available in subcutaneous format, but many can be adapted for orthotopic implantation or integrated into humanized systems for specific immune-oncology applications.

What are the licensing or access requirements for using pretreated models?

Access to models is governed by a standard study agreement or material transfer agreement. We don’t charge additional licensing fees for model use within our CRO services. All studies are conducted within Champions’ facilities under strict quality and ethical guidelines.

Do you offer study design support specific to resistance or late-line treatment settings?

Yes. Our scientific team works with you to design protocols that replicate real-world clinical conditions, incorporating relevant prior lines of therapy, biomarker tracking, and combination schedules tailored to your pipeline.