Syngeneic Mouse Models
A Syngeneic Mouse Model is a preclinical in vivo model that is used to evaluate therapeutic candidates in mice that have a complete and functional immune system. Specifically shown below, a tumor cell line from an inbred mouse strain is expanded in vitro and then implanted into the same inbred mouse strain with a fully intact immune system. These types of in vivo models have become ideal for testing innovative immune-oncology therapeutics preclinically.
Champions Oncology has a wide range of well characterized syngeneic mouse models with responses to immune checkpoint inhibitors (e.g. anti-PD-1 and anti-CTLA-4). Our endpoint analyses include profiling of immune cells by flow cytometry, immunohistochemistry and bioanalytical chemistry and genetic evaluation by WES or RNA-seq.
We run quarterly Syngeneic Screens on a range of our syngeneic mouse models which always include free vehicle response data as well as significantly discounted treatment arms. Each screen is available to our clients on a first-come, first serve basis as study animal numbers are limited.
Syngeneic Mouse Model Process