On Demand Webinar

Genomic DNA editing is a continuous process that occurs during the entire cell life span. The type and frequency of these modifications can be related to the physiological or pathological activity of intrinsic mechanisms such as DNA surveillance and repair or to extrinsic events that may induce an alteration of DNA sequence by exposure to agents that directly or indirectly induce accumulations of DNA alterations. In the past few years, large-scale analyses have revealed mutational signatures across human cancer types. These signatures can be used as markers of defective internal processes, such as DNA repair deficiency, or external exposures, such as carcinogens, like tobacco, or genotoxic therapies such as radiation and chemotherapy.

In this Poster QuickTake, we take a deep dive into evaluating mutational signatures in PDX models to give a better understanding of drug responses and companion biomarker identification.

Meet Our Presenter:

Stefano Cairo, PhD, Sr. Global Scientific Director at Champions Oncology

Stefano Cairo, PhD has extensive experience in the field of oncology and rare diseases. Stefano is currently serving as the Senior Global Scientific Director at Champions Oncology, Inc. Prior to this, they held the position of Head of Research and Development at XenTech, where they led multiple projects focused on molecular and pharmaceutical characterization of preclinical models and establishing a preclinical cohort for pediatric liver cancer. Stefano also worked as a Researcher at the University of Ferrara and as a Post-doctoral fellow at Institut Pasteur, where they specialized in the molecular and functional characterization of hepatoblastoma. Stefano began their career as a PhD student and post-doc at Tigem, focusing on the identification and functional characterization of genes related to rare human diseases and cancer.

Stefano Cairo, PhD, began their education in 1985 at Liceo Scientifico Bertrand Russell in Italy, where they obtained their High School Diploma in an unspecified field of study. Stefano then pursued their undergraduate studies in Biology at Università degli Studi di Milano from 1990 to 1996, earning a Master of Arts (MA) degree. Continuing their academic journey, they attended The Open University from 2001 to 2004, specializing in Biology with a focus on human genetics, culminating in the completion of a Doctor of Philosophy (PhD) degree in this field.