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DLBCL Ex Vivo Screen

Champions' premier DLBCL Ex Vivo Screen provides a robust bank of pretreated and treatment-naïve PDX models to assess breakthrough diffuse large B-cell lymphoma therapeutics

Now Enrolling until March 27th, 2026

 

 

Request more information on our In Vivo Screen for APC/β-Catenin Dysregulation

Clinically Relevant DLBCL Models with Key Mutations & Molecular Characteristics

Evaluate your Diffuse Large B-Cell Lymphoma drug candidates on our advanced ex vivo screening platform, which features nine pretreated and treatment-naïve patient-derived xenograft (PDX) DLBCL models. Our carefully curated collection includes models treated with advanced cancer therapies like CAR-T, RICE, and R-CHOP.  

 Clinically Relevant Models

Living bank of 9 clinically relevant PDX models with key mutations and molecular characteristics.  

Pretreated PDX Models

Established from tumor biopsies from patients pretreated with latest generation therapies

Multi-omic Characterization

Clinical annotations coupled with molecular datasets and in vivo responses 

Champions' leading DLBCL Ex Vivo Screen showcases 9 PDX models, each reflecting key clinical characteristics, mutations, and pretreatment history. 

  • Includes Diffuse Large B-Cell Lymphoma models pretreated with advanced cancer therapies such as CAR-T, RICE, and R-CHOP.   
  • Complete model characterization (clinical data, NGS analysis, proteomics, phospho-proteomics, and more).
  • Several endpoint data options available including Flow Cytometry and IHC to quantify target expression and critical phenotypical changes (available upon request).
  • Terminal tumor collections for target validation is available upon request (Snap Frozen/FFPE)
  • No minimum to enroll & 50% off a Standard of Care Agent arm (selected by Champions)
Example Responses to SoC - Ex Vivo
DLBCL in vivo screen may 2024 standard of care Reponses

Treatment responses of three DLBCL PDX models, CTG-3064, CTG-3793, and CTG-3803, to standards-of-care.

DLBCL Clustering-1
DLBCL Ex Vivo Screen PDX Models Mutation Clustering

Utilizing Lumin, our Clustering Heatmap tool is a web-based application designed to visually interpret and analyze complex data through interactive and shareable hierarchically clustered heatmaps. 

  • Visualize expression signatures and the prevalence of driver mutations in each PDX model.
  • Gain profound insights by exploring RNA-seq, WES, proteomics, and phospho-proteomics datasets.
  • Harness quality data from extensive datasets to drive informed decision-making.