At A Glance
- Model systems
- PDX and CDX, all tumor types
- Data types
- Genomic, proteomic, clinical
- Patient records
- 12,000+ patients
Champions Oncology · Model selection
See a model’s full molecular record before you shortlist it
Lumin is the browsable database behind every Champions Oncology model — molecular profile, treatment history, and prior drug response, linked before you build a cohort.
PDX and CDX coverageMulti-omic profilingClinical annotation attached
Overview
The record behind a model matters more than the name on it
Most model catalogs give you a tumor type and a passage number — not the molecular profile, treatment history, or prior drug response that actually predicts whether a model can answer your question. Without that record, you either choose on incomplete information or wait on a summary emailed back and forth before you can shortlist anything with real confidence.
Lumin puts that record in front of you directly. Every model in the panel carries whole exome and transcriptome sequencing, proteomic profiling where available, clinical annotation, and — for many models — a documented history of prior treatment and response, drawn from a patient bank that has grown past the 12,000 patients last published here, placeholder pending confirmation. You browse the same data our scientists use to build a cohort.
Access covers the full patient-derived xenograft and cell line-derived xenograft panel, spanning solid tumor and hematological malignancies. Lumin does not replace a consultation: molecular data narrows the field, but a scientist still reviews feasibility, coverage gaps, and study design once you have a shortlist worth discussing.
Why researchers use Lumin
Model selection built on data you can see
A model summary on a page is not the same as a model’s actual record. Lumin gives you the record itself — sequencing, proteomics, clinical history — so a candidate can be ruled in or out before it reaches a consultation.
That matters most when a program is narrowing fast: a resistance profile, a specific alteration, or a prior therapy class can eliminate most of a panel in minutes, rather than after several rounds of email.
01
Browse before you commit
Review a model’s full molecular and clinical record before it enters any conversation with our team.
02
Filter on what matters
Narrow the panel by tumor type, mutation status, and treatment history instead of scanning a static list.
03
See treatment history
Prior response to standard-of-care agents is attached to a model, where documented, not held back until you ask.
04
One database, every study
The same Lumin record underlies model selection across our full PDX, CDX, and specialty testing programs.
What’s inside
The data behind every model in the panel
Every entry in Lumin carries the characterization behind it, not just a name and a tumor type. Coverage varies by model — check what’s confirmed before you build a cohort around it.
| Data Type | Method | What it shows | Status |
|---|---|---|---|
| Whole exome sequencing | WES | Somatic mutation and copy-number profile | Standard |
| Transcriptome profiling | RNA-seq | Expression and pathway activity | Standard |
| Proteomics | LC-MS/MS | Protein abundance across the tumor | Cohort-dependent |
| Phospho-proteomics | LC-MS/MS | Pathway activation state | Cohort-dependent |
| Clinical annotation | Chart abstraction | Treatment history, stage, and outcome | Standard |
| Histopathology | H&E, IHC | Tumor architecture and marker expression | Standard |
| Drug response history | In vivo dosing record | Prior response to standard-of-care agents | On request |
| Growth kinetics | Serial caliper measurement | Take rate and doubling time | On request |
Data availability reflects the general panel in Lumin; confirm coverage for a specific model before finalizing a cohort.
Interface
What you can actually do inside Lumin
Lumin is not a static PDF of models. It’s a working interface you filter, sort, and export from — built for narrowing a panel down to a shortlist worth a consultation, not for browsing for its own sake.
Filter by tumor type
Narrow the panel to a single indication or a related group before you look at anything else.
Filter by mutation status
Isolate models carrying a specific alteration, or exclude ones that don’t carry it, in one step.
Filter by treatment history
Find models with documented prior exposure to a drug class, including resistant and treatment-naive cohorts side by side.
Open a full model profile
Review sequencing, proteomics, histopathology, and clinical annotation for one model before you shortlist it.
Compare models side by side
Line up candidate models against each other on the same molecular and clinical fields.
Export a shortlist
Take a candidate list into your model selection consultation instead of starting that conversation from scratch.
How it fits
From browsing Lumin to a locked cohort in five steps
Lumin narrows the field. A scientist still reviews the shortlist before anything is finalized, so a cohort is never built on database access alone.
- 01
Browse
Filter the panel by tumor type, mutation status, and treatment history to see what’s actually available.Exit criterion — candidate models identified and reviewed.
- 02
Shortlist
Pull the models whose molecular and clinical record fits your study question into a working list.Exit criterion — shortlist compiled from the Lumin record.
- 03
Consult
A scientist reviews the shortlist against your endpoints and flags any coverage gaps before you commit.Exit criterion — feasibility and coverage gaps confirmed.
- 04
Confirm
Study design, treatment arms, and endpoints are agreed in writing against the confirmed cohort.Exit criterion — cohort and study design signed off.
- 05
Execute
Models move into implantation or randomization on the schedule both teams agreed during study design.Exit criterion — study underway on the confirmed cohort.
Already know the tumor type and profile you need?
Request log-in access and start narrowing the panel yourself, or talk to a scientist first if you’re unsure where to start.
FAQ
What researchers ask before requesting access
Answers to the questions that come up most before a team starts browsing the panel.
Lumin access is self-serve: you browse the model panel and its molecular and clinical record on your own. A study request is the next step, where a scientist reviews your shortlist, confirms feasibility, and agrees a design with you before anything is scheduled.
Characterization runs before a model enters the panel, and new models and profiling are added on an ongoing basis. Coverage is not identical across every line — a model’s page shows exactly what’s confirmed for that model, not an aggregate claim for the whole panel.
Yes. Access is granted to review the panel during early-stage planning, not only once a study is already scoped. Many teams request access specifically to narrow a field of candidates before they bring a question to a scientist.
Flag the tumor type, mutation, or treatment history you’re looking for when you request access or during a model selection consultation. Our team will point you to the closest match already in the panel or discuss whether new profiling can be scoped.
Access is intended for researchers and program leads evaluating models for an oncology research program, at a company or institution, not for personal or unaffiliated use. Confirm your organization and role in the request form.
Related services
Where Lumin shows up
Model selection in Lumin sits underneath most of our in vivo work — these are the programs that pull from it most directly.
Solid tumor PDX
The core PDX panel Lumin indexes, with the deepest molecular and clinical coverage.
Pretreated PDX
Filter directly to resistant and treatment-exposed cohorts inside the same Lumin record.
Mouse clinical trials
Cohort-level dosing studies drawn from models shortlisted the same way, at panel scale.
Radiopharmaceutical testing
PDX and CDX cohorts matched to confirmed target expression from the Lumin database.
Get started
Request your Lumin log-in credentials
Tell us your organization, role, and the tumor types or research questions you’re working on. Include any specific mutation, treatment history, or endpoint you already know you’ll need, so our team can confirm the right level of access before you start browsing.
A scientist reviews every request, not an automated approval
Access confirmed within one to two business days
No study commitment required to browse the panel