THP-1

THP-1 (Leukemia CDX Model) 

The THP-1 line was derived from a patient with acute monocytic leukemia. It is a suspension cell line with features of monocyte lineage. THP-1 is widely used in hematology drug development and biomarker studies. Its reproducibility supports translational leukemia pipelines. 

Key Features: 

• Derived from acute monocytic leukemia. 

• Monocyte lineage markers. 

• Suspension growth morphology. 

• Tumorigenic in xenografts. 

Applications: 
THP-1 supports drug discovery in monocytic leukemia. Researchers use it to study differentiation, resistance, and biomarker development. It is also applied in immunology studies due to monocyte lineage properties. Its stability makes it widely adopted in hematology research.