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CDX

SW620

Description

SW620 (Colorectal Cancer CDX Model) 

The SW620 colorectal cancer line was derived from a lymph node metastasis of colon adenocarcinoma. It is genetically related to SW480, which was established from the same patient’s primary tumor. SW620 represents advanced and metastatic colorectal cancer biology. Its reproducibility makes it valuable for translational studies. 

Key Features: 

  • Derived from metastatic colorectal adenocarcinoma. 
  • Sister line to SW480. 
  • Represents advanced colorectal cancer. 
  • Tumorigenic in xenografts. 

Applications: 
SW620 is used in advanced colorectal cancer drug discovery. Researchers apply it in biomarker and resistance mechanism studies. It is often used alongside SW480 to study tumor progression. Its metastatic biology makes it valuable for translational CRC pipelines.

Details
Tumor Type
Colorectal
Tumor Subtype
Dukes' type C, Colorectal Adenocarcinoma
Organism
Human
Mouse Sex
Female
Mouse Strain
NOG
Mutated Genes
APC
Mutation: p.Q1338Ter
Effect: Stop-Gain
Impact: Pathogenic & Likely Pathogenic
KRAS
Mutation: p.G12V
Effect: Missense Variant
Impact: Likely Pathogenic & Pathogenic
TP53
Mutation: p.P309S
Effect: Missense Variant
Impact: Uncertain Significance
Mutation: p.R273H
Effect: Missense Variant
Impact: Pathogenic / Likely Pathogenic & Pathogenic & Likely Pathogenic
Expression Data
Growth Curve
View on Lumin