CDX
SW480
Tumor indication
Colorectal
Tumor subtype
Dukes' type B, Colorectal Adenocarcinoma
Description
SW480 (Colorectal Cancer CDX Model)
The SW480 line was derived from a primary colorectal adenocarcinoma. It carries a KRAS mutation and reflects early-stage colorectal cancer. SW480 is widely applied in drug discovery and biomarker research. Its reproducibility makes it a trusted colon cancer model.
Key Features:
- Derived from colorectal adenocarcinoma.
- KRAS-mutant colorectal cancer line.
- Epithelial morphology.
- Tumorigenic in xenografts.
Applications:
SW480 supports therapeutic research for KRAS-driven colorectal cancer. It is used in biomarker validation and mechanism-of-resistance studies. Researchers apply it in comparative studies with metastatic models. Its defined biology provides translational value in drug testing.
Details
- Tumor indication
- Colorectal
- Tumor subtype
- Dukes' type B, Colorectal Adenocarcinoma
- Organism
- Human
- Mouse sex
- Female
- Lumin data
- Proteomics, RNA-Seq, WES
Mutated genes
Select a gene to see the variants recorded for this line.
Gene expression
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| Gene | Expression |
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Expression measured across the Champions panel.
Lumin data
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