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CDX

SW480

Description

SW480 (Colorectal Cancer CDX Model) 

The SW480 line was derived from a primary colorectal adenocarcinoma. It carries a KRAS mutation and reflects early-stage colorectal cancer. SW480 is widely applied in drug discovery and biomarker research. Its reproducibility makes it a trusted colon cancer model. 

Key Features: 

  • Derived from colorectal adenocarcinoma. 
  • KRAS-mutant colorectal cancer line. 
  • Epithelial morphology. 
  • Tumorigenic in xenografts. 

Applications: 
SW480 supports therapeutic research for KRAS-driven colorectal cancer. It is used in biomarker validation and mechanism-of-resistance studies. Researchers apply it in comparative studies with metastatic models. Its defined biology provides translational value in drug testing.

Details
Tumor Type
Colorectal
Tumor Subtype
Dukes' type B, Colorectal Adenocarcinoma
Organism
Human
Mouse Sex
Female
Mouse Strain
NOG
Mutated Genes
APC
Mutation: p.Q1338Ter
Effect: Stop-Gain
Impact: Pathogenic & Likely Pathogenic
ATM
Mutation: p.R2461P
Effect: Missense Variant
Impact: Uncertain Significance
KRAS
Mutation: p.G12V
Effect: Missense Variant
Impact: Likely Pathogenic & Pathogenic
TP53
Mutation: p.P309S
Effect: Missense Variant
Impact: Uncertain Significance
Mutation: p.R273H
Effect: Missense Variant
Impact: Pathogenic / Likely Pathogenic & Pathogenic & Likely Pathogenic
Lumin Data
Proteomics RNASeq WES
Expression Data
Growth Curve
View on Lumin