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CDX

SK-UT-1

Description

SK-UT-1 (Uterine Cancer CDX Model) 

The SK-UT-1 line was derived from a uterine leiomyosarcoma. It represents a rare and aggressive form of uterine cancer. SK-UT-1 has been applied in preclinical sarcoma and gynecologic oncology research. Its reproducibility supports translational rare tumor studies. 

Key Features: 

  • Derived from uterine leiomyosarcoma. 
  • Aggressive sarcoma phenotype. 
  • Tumorigenic in xenografts. 
  • Rare tumor biology. 

Applications: 
SK-UT-1 is used in rare tumor drug discovery, particularly in leiomyosarcoma. Researchers apply it in biomarker development and targeted therapy studies. It supports translational pipelines for gynecologic oncology. Its rarity makes it valuable for focused drug testing.

Details
Tumor Type
Uterine
Tumor Subtype
Uterine Leiomyosarcoma
Organism
Human
Mouse Sex
Female
Mouse Strain
Athymic Nude
Mutated Genes
ALK
Mutation: p.R1192Q
Effect: Missense Variant
Impact: Uncertain Significance
APC
Mutation: p.Q1096Ter
Effect: Stop-Gain
Impact: Pathogenic
Mutation: p.T1556LfsTer9
Effect: Frameshift Variant
Impact: Pathogenic
ARID1A
Mutation: p.G276EfsTer87
Effect: Frameshift Variant
Mutation: p.P1326RfsTer155
Effect: Frameshift Variant
ARID1B
Mutation: p.Q1982Ter
Effect: Stop-Gain
Mutation: p.Q2157Ter
Effect: Stop-Gain
Impact: Pathogenic
MSH2
Mutation: p.T788SfsTer10
Effect: Frameshift Variant
Impact: Likely Pathogenic
PIK3CA
Mutation: p.R88Q
Effect: Missense Variant
Impact: Pathogenic & Likely Pathogenic
TP53
Mutation: p.R175H
Effect: Missense Variant
Impact: Not Provided & Likely Pathogenic & Pathogenic
Mutation: p.R248Q
Effect: Missense Variant
Impact: Pathogenic / Likely Pathogenic & Likely Pathogenic & Pathogenic
TSC2
Mutation: p.Q90Ter
Effect: Stop-Gain
Impact: Pathogenic & Not Provided
Lumin Data
Proteomics RNASeq WES
Expression Data
Growth Curve
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