CDX
SK-N-MC
Tumor indication
Sarcoma
Tumor subtype
Neuroepithelioma, Askin's tumor
Description
SK-N-MC (Ewing Sarcoma CDX Model)
The SK-N-MC line was derived from a metastatic Ewing sarcoma lesion. It harbors the EWSR1-FLI1 fusion gene, characteristic of this pediatric cancer. SK-N-MC is widely used in preclinical sarcoma research. Its reproducibility ensures consistent results in translational studies.
Key Features:
- Derived from Ewing sarcoma metastasis.
- Contains EWSR1-FLI1 fusion gene.
- Pediatric sarcoma biology.
- Tumorigenic in xenografts.
Applications:
SK-N-MC supports pediatric sarcoma drug discovery and biomarker validation. Researchers use it to study EWSR1-FLI1 biology and targeted therapies. It is applied in resistance and mechanistic studies. Its defined fusion gene makes it clinically relevant.
Details
- Tumor indication
- Sarcoma
- Tumor subtype
- Neuroepithelioma, Askin's tumor
- Organism
- Human
- Mouse sex
- Female
- Lumin data
- Proteomics, RNA-Seq, WES
Gene expression
Show all values
| Gene | Expression |
|---|
Expression measured across the Champions panel.
Lumin data
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