SK-N-MC

SK-N-MC (Ewing Sarcoma CDX Model) 

The SK-N-MC line was derived from a metastatic Ewing sarcoma lesion. It harbors the EWSR1-FLI1 fusion gene, characteristic of this pediatric cancer. SK-N-MC is widely used in preclinical sarcoma research. Its reproducibility ensures consistent results in translational studies. 

Key Features: 

• Derived from Ewing sarcoma metastasis. 

• Contains EWSR1-FLI1 fusion gene. 

• Pediatric sarcoma biology. 

• Tumorigenic in xenografts. 

Applications: 
SK-N-MC supports pediatric sarcoma drug discovery and biomarker validation. Researchers use it to study EWSR1-FLI1 biology and targeted therapies. It is applied in resistance and mechanistic studies. Its defined fusion gene makes it clinically relevant.