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CDX

OV-90

Description

OV-90 (Ovarian Cancer CDX Model) 

The OV-90 line was derived from ascites of a patient with high-grade serous ovarian carcinoma. It represents an aggressive ovarian cancer subtype. OV-90 is widely used in drug testing and biomarker research. Its aggressive growth and reproducibility make it valuable for translational research. 

Key Features: 

  • Derived from high-grade serous ovarian carcinoma. 
  • Represents advanced ovarian cancer. 
  • Aggressive xenograft growth. 
  • Epithelial carcinoma morphology. 

Applications: 
OV-90 is applied in studies of ovarian cancer therapeutics, including chemotherapy and targeted therapy. Researchers use it to explore resistance mechanisms in serous ovarian carcinoma. It supports biomarker identification for ovarian cancer treatment. Its stability ensures consistent outcomes in preclinical pipelines.

Details
Ovarian
Ovarian Serous Adenocarcinoma
Human
Female
Athymic Nude
Mutated Genes
SMAD4
Mutation: p.R445Ter
Effect: Stop-Gain
Impact: Pathogenic
*Data provided by DepMap
TP53
Mutation: p.S215R
Effect: Missense Variant
Impact: Likely Pathogenic & Uncertain Significance
Expression Data
Growth Curve