MKN-45

MKN-45 (Gastric Cancer CDX Model) 

The MKN-45 gastric cancer line was derived from a poorly differentiated stomach adenocarcinoma. It is c-MET–amplified, making it clinically relevant for targeted therapy research. MKN-45 is widely applied in drug screening and biomarker studies for gastric cancer. Its defined mutation profile provides translational value in oncology research. 

Key Features: 

• Derived from poorly differentiated gastric adenocarcinoma. 

• c-MET amplification. 

• Aggressive tumor growth in xenografts. 

• Reliable gastric cancer research model. 

Applications: 
MKN-45 supports research into c-MET–targeted therapies. It is also used to explore drug resistance and biomarker validation in gastric cancer. Researchers employ it in translational studies of stomach cancer progression. Its reproducibility makes it valuable for drug development pipelines.