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CDX

LoVo

Description

LoVo (Colorectal Cancer CDX Model) 

The LoVo colorectal cancer cell line was derived from a metastatic adenocarcinoma of the colon. It represents advanced-stage colorectal disease. LoVo is microsatellite instability–high (MSI-H), making it a useful model for studies of mismatch repair deficiency. Its reproducibility has made it a standard colon cancer research model. 

Key Features: 

  • Derived from metastatic colorectal adenocarcinoma. 
  • MSI-high, mismatch repair–deficient. 
  • Epithelial morphology with glandular features. 
  • Tumorigenic in xenografts. 

Applications: 
LoVo is used in drug screening and biomarker development for colorectal cancer. Researchers employ it to study MSI-H biology and immunotherapy responsiveness. It supports resistance mechanism studies in advanced colon cancer. Its stability ensures reliability in translational pipelines.

Details
Tumor Type
Bowel
Tumor Subtype
Colorectal Adenocarcinoma
Organism
Human
Mouse Sex
Female
Mouse Strain
Athymic Nude
Mutated Genes
ALK
Mutation: p.G1580V
Effect: Missense Variant
*Data provided by DepMap
APC
Mutation: p.M1431CfsTer42
Effect: Frameshift Variant
Impact: Pathogenic
*Data provided by DepMap
Mutation: p.R1114Ter
Effect: Stop-Gain
Impact: Pathogenic & Likely Pathogenic
*Data provided by DepMap
Mutation: p.R2816Q
Effect: Missense Variant
Impact: Conflicting Interpretations Of Pathogenicity & Uncertain Significance
*Data provided by DepMap
ARID1A
Mutation: p.F2141SfsTer59
Effect: Frameshift Variant
*Data provided by DepMap
KRAS
Mutation: p.G13D
Effect: Missense Variant
Impact: Likely Pathogenic & Not Provided & Pathogenic & Uncertain Significance
*Data provided by DepMap
Expression Data (provided by DepMap)
Growth Curve
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