CDX
LoVo
Tumor indication
Bowel
Tumor subtype
Colorectal Adenocarcinoma
Description
LoVo (Colorectal Cancer CDX Model)
The LoVo colorectal cancer cell line was derived from a metastatic adenocarcinoma of the colon. It represents advanced-stage colorectal disease. LoVo is microsatellite instability–high (MSI-H), making it a useful model for studies of mismatch repair deficiency. Its reproducibility has made it a standard colon cancer research model.
Key Features:
- Derived from metastatic colorectal adenocarcinoma.
- MSI-high, mismatch repair–deficient.
- Epithelial morphology with glandular features.
- Tumorigenic in xenografts.
Applications:
LoVo is used in drug screening and biomarker development for colorectal cancer. Researchers employ it to study MSI-H biology and immunotherapy responsiveness. It supports resistance mechanism studies in advanced colon cancer. Its stability ensures reliability in translational pipelines.
Details
- Tumor indication
- Bowel
- Tumor subtype
- Colorectal Adenocarcinoma
- Organism
- Human
- Mouse sex
- Female
Mutated genes
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Gene expression
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| Gene | Expression |
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Expression measured across the Champions panel.
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