JeKo-1

JeKo-1 (Mantle Cell Lymphoma CDX Model) 

The JeKo-1 cell line was derived from a patient with mantle cell lymphoma (MCL). It represents an aggressive B-cell non-Hodgkin’s lymphoma. JeKo-1 is commonly used in hematology research and therapeutic evaluation. Its reproducibility makes it a reliable preclinical model for lymphoma studies. 

Key Features: 

• Derived from mantle cell lymphoma. 

• B-cell non-Hodgkin’s lymphoma line. 

• Aggressive growth in xenograft systems. 

• Suitable for drug screening studies. 

Applications: 
JeKo-1 supports MCL drug discovery and biomarker validation. It is used to evaluate targeted agents and combination therapies. Researchers study signaling pathways and mechanisms of resistance with this model. Its translational relevance has made it a widely adopted lymphoma model.