Huh-7

Huh-7 (Liver Cancer CDX Model) 

The Huh-7 liver cancer line was established from a hepatocellular carcinoma. It is p53-mutant and represents a well-characterized HCC model. Huh-7 has been applied in antiviral and oncologic research due to its permissiveness to hepatitis C virus. Its reproducibility makes it a versatile model for liver cancer research. 

Key Features: 

• Derived from hepatocellular carcinoma. 

• TP53-mutant liver cancer line. 

• Permissive to hepatitis C virus infection. 

• Consistent xenograft tumorigenicity. 

Applications: 
Huh-7 supports studies of HCC drug development and biomarker validation. It is also widely used in viral oncology research. Researchers employ it to evaluate novel therapeutics targeting p53-deficient cancers. Its versatility extends across oncology and infectious disease studies.