CDX
Huh-7
Tumor indication
Liver
Tumor subtype
Hepatocellular Carcinoma
Description
Huh-7 (Liver Cancer CDX Model)
The Huh-7 liver cancer line was established from a hepatocellular carcinoma. It is p53-mutant and represents a well-characterized HCC model. Huh-7 has been applied in antiviral and oncologic research due to its permissiveness to hepatitis C virus. Its reproducibility makes it a versatile model for liver cancer research.
Key Features:
- Derived from hepatocellular carcinoma.
- TP53-mutant liver cancer line.
- Permissive to hepatitis C virus infection.
- Consistent xenograft tumorigenicity.
Applications:
Huh-7 supports studies of HCC drug development and biomarker validation. It is also widely used in viral oncology research. Researchers employ it to evaluate novel therapeutics targeting p53-deficient cancers. Its versatility extends across oncology and infectious disease studies.
Details
- Tumor indication
- Liver
- Tumor subtype
- Hepatocellular Carcinoma
- Organism
- Human
- Mouse sex
- Female
Mutated genes
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Gene expression
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| Gene | Expression |
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Expression measured across the Champions panel.
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