HT-1080

HT-1080 (Fibrosarcoma CDX Model) 

The HT-1080 fibrosarcoma line was derived from a human soft tissue sarcoma. It is characterized by mutations in NRAS, reflecting oncogenic drivers of sarcoma progression. HT-1080 has been widely used in preclinical sarcoma studies. Its reproducible growth supports both mechanistic and drug testing research. 

Key Features: 

• Derived from human fibrosarcoma. 

• NRAS-mutant sarcoma model. 

• Mesenchymal morphology. 

• Robust tumorigenicity in xenografts. 

Applications: 
HT-1080 supports studies of sarcoma progression and targeted therapy evaluation. Researchers use it to test novel agents directed at RAS signaling. It is also applied in invasion and metastasis research. Its reproducibility makes it a trusted sarcoma model in translational pipelines.