Hep G2

Hep G2 (Liver Cancer CDX Model) 

The Hep G2 liver cancer cell line was derived from a 15-year-old patient with hepatocellular carcinoma. It retains many metabolic functions of normal hepatocytes, making it a unique HCC model. Hep G2 is widely used in drug metabolism, toxicity, and cancer research. Its stable biology makes it a key preclinical tool. 

Key Features: 

• Derived from hepatocellular carcinoma. 

• Retains hepatocyte metabolic activity. 

• Produces alpha-fetoprotein (AFP). 

• Tumorigenic in xenograft systems. 

Applications: 
Hep G2 is used in HCC therapeutic testing and biomarker validation. It is also applied in liver function and toxicity studies due to preserved metabolic traits. Researchers use it for mechanistic studies of liver cancer progression. Its versatility spans oncology and pharmacology research.