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CDX

HCT 116

Description

HCT 116 (Colorectal Cancer CDX Model) 

The HCT 116 colorectal cancer line was established from a patient with colon carcinoma. It carries mutations in KRAS and PIK3CA, both relevant drivers in colorectal cancer. HCT 116 is one of the most widely used colon cancer models in oncology research. Its stable growth and reproducibility make it a mainstay in preclinical studies. 

Key Features: 

  • Derived from colorectal carcinoma. 
  • KRAS and PIK3CA mutations. 
  • Microsatellite instability (MSI-high). 
  • Reliable tumor formation in xenografts. 

Applications: 
HCT 116 is applied in drug screening and biomarker studies for colorectal cancer. Researchers use it to explore KRAS-driven resistance and PI3K-targeted therapies. It is also valuable for studies of MSI-high tumor biology. Its reproducibility makes it suitable for translational drug development.

Details
Tumor Type
Colorectal
Tumor Subtype
Colorectal Adenocarcinoma
Organism
Human
Mouse Sex
Female
Mouse Strain
Athymic Nude
Mutated Genes
ABL1
Mutation: p.Y257C
Effect: Missense Variant
ATRX
Mutation: p.T1529del
Effect: Inframe Deletion
BRCA2
Mutation: p.I2675DfsTer6
Effect: Frameshift Variant
Impact: Pathogenic
CTNNB1
Mutation: p.S45del
Effect: Inframe Deletion
Impact: Pathogenic & Other
FANCA
Mutation: p.P615HfsTer25
Effect: Frameshift Variant
KRAS
Mutation: p.G13D
Effect: Missense Variant
Impact: Likely Pathogenic & Not Provided & Pathogenic & Uncertain Significance
MERTK
Mutation: p.R722Ter
Effect: Stop-Gain
Impact: Pathogenic & Likely Pathogenic
MLH1
Mutation: p.S252Ter
Effect: Stop-Gain
Impact: Pathogenic
MSH6
Mutation: p.F1088LfsTer5
Effect: Frameshift Variant
Impact: Likely Pathogenic & Pathogenic
PIK3CA
Mutation: p.H1047R
Effect: Missense Variant
Impact: Pathogenic / Likely Pathogenic & Likely Pathogenic & Pathogenic
Lumin Data
RNASeq WES
Expression Data
Growth Curve
View on Lumin