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CDX

DLD-1

Description

DLD-1 (Colorectal Cancer CDX Model) 

The DLD-1 colorectal cancer cell line was derived from a patient with adenocarcinoma of the colon. It carries a KRAS mutation, representing a common driver in colorectal cancer. DLD-1 is widely used in colon cancer drug discovery and resistance studies. Its reproducibility has made it a staple in preclinical pipelines. 

Key Features: 

  • Derived from colorectal adenocarcinoma. 
  • KRAS-mutant colorectal cancer model. 
  • Maintains epithelial morphology. 
  • Consistent xenograft tumor growth. 

Applications: 
DLD-1 is applied in studies of KRAS-driven colorectal cancer biology. It supports drug discovery and biomarker validation for targeted therapies. Researchers use it to explore resistance to standard chemotherapies. Its defined mutation status provides strong translational relevance.

Details
Tumor Type
Colorectal
Tumor Subtype
Dukes' type C, colorectal adenocarcinoma
Organism
Human
Mouse Sex
Female
Mouse Strain
Athymic Nude
Mutated Genes
APC
Mutation: p.I1417LfsTer2
Effect: Frameshift Variant
*Data provided by DepMap
Mutation: p.K993N
Effect: Missense Variant
*Data provided by DepMap
Mutation: p.R2166Ter
Effect: Stop-Gain
Impact: Pathogenic
*Data provided by DepMap
Mutation: p.R727M
Effect: Missense Variant
*Data provided by DepMap
ARID1B
Mutation: p.G413Ter
Effect: Stop-Gain
*Data provided by DepMap
Mutation: p.R1747Ter
Effect: Stop-Gain
Impact: Pathogenic
*Data provided by DepMap
ATR
Mutation: p.I1851V
Effect: Missense Variant
*Data provided by DepMap
ATRX
Mutation: p.L629R
Effect: Missense Variant
*Data provided by DepMap
BRCA2
Mutation: p.C1200Ter
Effect: Frameshift Variant
Impact: Pathogenic
*Data provided by DepMap
Mutation: p.N1784TfsTer7
Effect: Frameshift Variant
Impact: Uncertain Significance & Not Provided & Pathogenic
*Data provided by DepMap
FANCA
Mutation: p.E1178Ter
Effect: Stop-Gain
*Data provided by DepMap
KRAS
Mutation: p.G13D
Effect: Missense Variant
Impact: Likely Pathogenic & Not Provided & Pathogenic & Uncertain Significance
*Data provided by DepMap
MSH6
Mutation: p.D1171Ter
Effect: Frameshift Variant
Impact: Pathogenic
*Data provided by DepMap
Mutation: p.L290Ter
Effect: Frameshift Variant
Impact: Pathogenic
*Data provided by DepMap
Mutation: p.R1172del
Effect: Inframe Deletion
*Data provided by DepMap
PIK3CA
Mutation: p.D549N
Effect: Missense Variant
Impact: Pathogenic
*Data provided by DepMap
Mutation: p.E545K
Effect: Missense Variant
Impact: Not Provided & Likely Pathogenic & Pathogenic & Pathogenic / Likely Pathogenic
*Data provided by DepMap
TP53
Mutation: p.S241F
Effect: Missense Variant
Impact: Likely Pathogenic & Pathogenic / Likely Pathogenic & Pathogenic
*Data provided by DepMap
Effect: Splice Acceptor Variant
Impact: Not Provided
*Data provided by DepMap
Lumin Data
Proteomics
Expression Data (provided by DepMap)
Growth Curve
View on Lumin