A-431

A-431 (Epidermoid Carcinoma CDX Model) 

The A-431 epidermoid carcinoma line was derived from a vulvar carcinoma. It is well known for very high expression of epidermal growth factor receptor (EGFR). This makes A-431 a gold standard model for EGFR-targeted drug development. Its reproducible biology supports both mechanistic and translational studies. 

Key Features: 

• Originates from vulvar epidermoid carcinoma. 

• Overexpresses EGFR at high levels. 

• Strong epithelial morphology. 

• Benchmark model for EGFR research. 

Applications: 
A-431 is used to test EGFR inhibitors and antibodies in preclinical research. It is applied in studies of EGFR signaling and downstream pathways. Researchers often use it to evaluate therapeutic efficacy in epithelial cancers. Its consistent overexpression makes it valuable for benchmarking targeted therapies.