<img alt="" src="https://secure.soil5hear.com/223550.png" style="display:none;">
Skip to content
CDX

22Rv1

Description

22Rv1 (Prostate Cancer CDX Model)

The 22Rv1 prostate cancer cell line was derived from a human prostate carcinoma xenograft. It is widely used to study advanced prostate cancer and castration-resistant disease. 22Rv1 expresses prostate-specific antigen (PSA) and carries androgen receptor mutations and splice variants. These traits make it a clinically relevant model for therapeutic resistance research. 

Key Features: 

  • Derived from a human prostate carcinoma xenograft. 
  • Expresses prostate-specific antigen (PSA). 
  • Contains androgen receptor mutations and splice variants. 
  • Supports both androgen-dependent and resistant growth. 

Applications: 
22Rv1 is a versatile CDX model for prostate cancer drug development. It is commonly applied in studies of androgen receptor biology and resistance pathways. Researchers use it to evaluate next-generation therapeutics for castration-resistant prostate cancer. Its reproducibility makes it valuable for biomarker validation and mechanistic research.

Details
Tumor Type
Prostate
Tumor Subtype
Prostate carcinoma
Organism
Human
Mouse Sex
Male
Mouse Strain
Athymic Nude
Mutated Genes
AR
Mutation: p.H875Y
Effect: Missense Variant
Impact: Pathogenic
ARID1A
Mutation: p.D1850GfsTer4
Effect: Frameshift Variant
ATM
Mutation: p.K1101E
Effect: Missense Variant
Impact: Uncertain Significance
BRAF
Mutation: p.L597R
Effect: Missense Variant
Impact: Pathogenic & Likely Pathogenic
BRCA2
Mutation: p.T3033NfsTer11
Effect: Frameshift Variant
Impact: Not Provided & Likely Pathogenic & Pathogenic
NOTCH2
Mutation: p.A1083SfsTer17
Effect: Frameshift Variant
Impact: Pathogenic
PIK3CA
Mutation: p.Q546R
Effect: Missense Variant
Impact: Pathogenic & Likely Pathogenic
TP53
Mutation: p.Q331R
Effect: Missense Variant, Splice Region Variant
Impact: Uncertain Significance
Mutation: p.V73WfsTer50
Effect: Frameshift Variant
Impact: Likely Pathogenic & Pathogenic
Lumin Data
Proteomics
Expression Data
Growth Curve
View on Lumin