Download Champions' AACR 2021 Poster
Unique 3D Organoids Autologous TIL Coculture Platform Enables High Throughput Immune-Oncology Drug Response Studies
Cancer progression and therapy response are influenced by complex interactions within the tumor microenvironment (TME), particularly involving immune cells. Traditional 2D cultures fail to replicate the 3D structures and immune biology of native tumors. To address this, patient-derived xenograft (PDX) models combined with autologous tumor-infiltrating lymphocytes (TILs) were developed to simulate the tumor-specific immune response. This innovative platform, utilizing 3D organoid cultures (PDXOs) with TILs, allows for high-throughput screening of immune-modulatory therapies and assessment of T cell infiltration and tumor cell killing in a clinically relevant model.
- Tumor progression and immune therapy responses are governed by complex TME interactions, which are difficult to replicate in traditional 2D cultures.
- Patient-derived xenograft (PDX) organoid (PDXO) models with autologous TILs simulate the tumor-specific immune response for immune-oncology studies.
- The platform enables high-throughput screening of immune therapies, tracking TIL infiltration, tumor cell killing, and cytokine changes in response to treatment.
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