Accelerate Your KRAS Drug Discovery with Clinically Relevant Ex Vivo Models
Champions Oncology’s KRASm Ex Vivo Screen provides access to a curated panel of patient-derived tumor models carrying clinically relevant KRAS mutations, including G12C, G12D, G12V, G12A, and G13D. These low-passage models are derived from our highly annotated PDX bank, offering unparalleled translational relevance for preclinical research.
14 Clinically Relevant Models
A curated panel of low-passage ex vivo models derived from patient tumors with key KRAS mutations for superior translational relevance.
Flexible, High-Throughput Screening
Available in both 96-well and 384-well plate formats, enabling efficient screening of multiple test agents per run.
Molecularly Annotated, Data-Rich Outputs
Each model includes comprehensive clinical annotations, molecular datasets, and CellTiter-Glo endpoints to inform actionable insights.
Champions' KRASmut Ex Vivo Screen features a curated panel of low-passage, patient-derived models carrying key KRAS mutations and clinical annotations. These models reflect clinically relevant characteristics and are optimized for ex vivo proliferation.
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Includes models suitable for evaluating agents targeting KRAS-mutant pathways and those resistant to targeted therapies and immunotherapies.
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Accelerated turnaround times, data delivery within 7 weeks
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Comprehensive model characterization provided, including clinical data, NGS analysis, and additional molecular datasets.
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Multiple endpoint data options available, such as CellTiter-Glo, with the option to collect samples for further analyses.
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No minimum enrollment required, and one Standard of Care Agent (RMC-6236) is included in each screen.
Our screen includes 14 models across colorectal, pancreatic, and NSCLC indications. Each model is annotated with KRAS mutation status and optimized for ex vivo proliferation.
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Model ID
|
Cancer Type
|
KRAS Mutation
|
|---|---|---|
|
CTG-0061
|
Colorectal
|
G12D
|
|
CTG-0064
|
Colorectal
|
G12V
|
|
CTG-0083
|
Colorectal
|
G12V
|
|
CTG-0654
|
Colorectal
|
G12D
|
|
CTG-0796
|
Colorectal
|
G12A
|
|
CTG-1885
|
NSCLC
|
G12V
|
|
CTG-2026
|
NSCLC
|
G12C
|
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CTG-2536
|
NSCLC
|
G12C
|
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CTG-2803
|
NSCLC
|
G12D
|
|
CTG-0286
|
Pancreatic
|
G12D
|
|
CTG-0492
|
Pancreatic
|
G12V
|
|
CTG-0955
|
Pancreatic
|
G12D
|
|
CTG-1150
|
Pancreatic
|
Q61R
|
|
CTG-2205
|
Pancreatic
|
G12V
|
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