Download Champions' latest AACR 2024 Poster

Recent advancements in engineered co-culture systems, like microfluidic organ-on-chips, address limitations observed  in modeling cell-cell and ECM interactions. These systems support long-term cell culture and continuous monitoring of byproducts to assess tissue function and viability. They also replicate organ-level structure, function, and physical forces such as cyclic strain and shear stress. In this poster, we demonstrate our Tumor-on-Chip (TOC) model, a complex co-culture system established from our TumorGraft3D (CTG3D) biobank at Champions Oncology.

•  TOCs prove to be a robust and powerful tool for studying the effect of microenvironmental factors in different cancer indications.
• The combination of DRAQ7 dye and high-content  imaging provides a reliable read-out to detect the drug response in cancer cells pre- and posttreatment.
• TOCs have the capacity to emulate the complex nature of tumors including physical forces that mimic in vivo cyclic strain and fluid shear stress as well as the access to both apical and basolateral sides of cancer cells.