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Systematic Analysis of Gene Mutations and Therapeutic Efficacy via Ex vivo Hematological VitroScreen Platform

A Champions AACR 2024 Poster


Acute myeloid leukemia (AML) is the most common hematological malignancy found in acute leukemia patients. There is shown to be a strong genetic correlation to mechanisms of drug resistance/ sensitivity in AML. e.g.FMS-like tyrosine kinase 3 gene (FLT3) mutation occurs in about 30% of patients. In 2019, a phase 3 clinical trial suggested that gilteritinib treatment resulted in significantly longer survival than salvage chemotherapy in relapsed or refractory FLT3-mutated AML patients. Targeting FLT3-mutant (mut) in AML has become one of the important therapeutic strategies in this decade. Besides, TP53 mut, TET2 mut, and the overexpression of various drug-resistance genes were also reported as important biomarkers that impact the sensitivity of drug treatments.

Champions Oncology’s hematological VitroScreen platform provides users with a powerful and cost-friendly option to screen the performance of new FLT3 inhibitors or other novel anti-neoplastic test agents. In addition, the Lumin platform integrates Champions’ tumor model multi-omic data and public datasets in one accessible platform for model selection and data interpretation.

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