<img alt="" src="https://secure.soil5hear.com/223550.png" style="display:none;">
Skip to content

 

Services

 

 

With the most up-to-date and relevant bank of preclinical research models mirroring clinical trial patient populations, a large portfolio of novel proprietary platforms, and validated clinical specialty testing expertise, Champions is the ideal partner to deliver success and accelerate your drug development process.

In Vivo Modeling

In Vivo Modeling

Champions' in vivo testing solutions include a range of preclinical models and services for the preclinical assessment of novel anticancer agents across all therapeutic modalities, including cell therapy and immune-oncology agents. Champions offers: 

  • The most clinically annotated, molecularly-characterized bank of over 1,400 solid tumor and hematological models
  • A growing bank of over 100 multi-omic characterized cell line-derived xenograft mouse models
  • Characterized syngeneic and humanized mouse models for testing innovative immune-oncology therapeutics across multiple mechanisms of action
Platforms_03
SOLID TUMOR PDX MODELS

Over 1,400 clinically relevant TumorGraft® models with correlation to clinical outcomes

Platforms_02
HEMATOLOGICAL MODELS

A unique collection of primary never-passaged patient samples, accurately mirroring the heterogeneity of hematologic malignancies

 
Platforms_01
SYNGENEIC MODELS

A collection of murine models across multiple indications, with a complete and functional mouse immune system

Platforms_05
CDX MODELS

Over 100 cell-line derived xenograft mouse models to determine the efficacy of therapeutics

Platforms_04
HUMANIZED MODELS

A diverse portfolio of Champions' ImmunoGraft® to assess the effect of therapeutics on functional components of the human immune system

Ex Vivo Proprietary Platforms

Champions' ex vivo proprietary platforms are developed by expert R&D scientists to deliver insights and solve complex preclinical industry issues. These platforms are: 

  • Novel, high-throughput screening platforms to deliver insights and derisk preclinical programs
  • Unique assays to assess mechanisms including cytotoxicity, proliferation, and infiltration
  • Coupled with multiple readouts to validate targets or screen various cancer indications
Ex Vivo Proprietary Platforms
Platforms_028
CELL LINE ASSAYS

Enable screening of cancer cell lines across all tumor indications for target validation and indication selection

Platforms_09
HEMATOLOGICAL VITROSCREEN

Test therapeutics in over 80 highly characterized primary, never-passaged hematological models from AML, ALL, CLL, MCL, and MM patients

Platforms_010
TUMORGRAFT3D PLATFORM

Evaluate therapeutic efficacy in Champions' matrix-free, multiclonal 3D ex-vivo culture established from superior PDX models 

Platforms_08
CO-CULTURE ASSAYS

Assess the effect therapeutic agents have on cancer cells and the immune system in the tumor microenvironment

ScientistsInLab

Clinical Specialty Testing

Champions is a clinical specialty testing lab offering high-complexity flow cytometry, plate-based assays, immunohistochemistry, and next-generation sequencing GCLP-compliant platforms. Champions operates at the highest standard of scientific excellence to provide superior results for each patient sample arriving onsite. As your clinical partner, Champions offers: 

  • Unrivaled expertise in study design and execution, sample logistics and processing, and data analysis of clinical samples
  • Validated and fully customizable assays and collection kits for each analysis
  • Optimum flexibility and operational readiness in each clinical assay and sample type to help you accomplish more with each test
Platforms_015
HIGH COMPLEXITY FLOW CYTOMETRY

High-quality, complex computational results with the ability to interrogate up to 30 parameters on each individual cell simultaneously within each patient sample. 

Platforms_012
LUMINEX & ELISA

Assess secreted protein levels longitudinally in clinical trials by mutiplex panel Luminex or custom-developed ELISA.  

Platforms_013
HISTOLOGY & IMMUNOHISTOCHEMISTRY

Evaluate target expression and assess morphological changes within patient tissues of interest.  

Platforms_014
NEXT GENERATION SEQUENCING

Determine patient segmentation and personalized medicine approaches based on bioinformatic and computational insights.  

Platforms_011
SAMPLE COLLECTION KITS & LOGISTICS

Tube and reagent types are customizable and streamlined to ensure collection kits are delivered to each clinical site prior to SIV.