Superiority Over Xenografts

Unlike traditional cell-lines-based xenografts, which have a very poor ability to accurately predict clinical success, Champions TumorGrafts™ have been shown to accurately correlate with specific patient outcomes. 

  • Our models maintain a very high degree of genetic correlation (94%) to the original tumor.
  • Champions TumorGrafts™ are established from the actual tumor sample, and not from a cell line that has been passaged in vitro, so:
  • Our models have a 3-dimensional, heterogeneous structure that is more representative of the human cancer and maintains the cancer stem cells and stromal components.
  • Because each model is derived from a single patient, Champions TumorGrafts™ can be molecularly characterized for targeted drug development in a manner in which xenografts cannot.

References:

  1. Hidalgo M et al. Activity of gemcitabine in direct patient derived xenografts predicts clinical outcome: validation of an in vivo model for drug development. J Clin Oncol 27:15s, 2009 (suppl; abstr 4528)
  2. Hidalgo M et al. A Pilot Study of Treatment Guided by Personalized Tumorgrafts in Patients with Advanced Cancer. Mol Cancer Ther August 2011 10:1311-1316
  3. Rubio-Viqueira B, Jimeno A, Cusatis G, et al. An in vivo platform for translational drug development in pancreatic cancer. Clin Cancer Res. 2006;12:4652-4661.
  4. Champions data on file.