Personalized TumorGrafts™ Have Helped People with a Variety of Cancers

Patients receiving treatment guided by Personalized TumorGraft™ testing have seen shrinkage of their tumor for a significant period of time1.

Successfully Evaluated Tumor Types Include:

Colon, Pancreas, Stomach, Esophagus, Lung, Breast, Sarcomas, Mesothelioma, Ovary, and others.

Treatment Solutions Evaluated:

Single-agent chemotherapy drugs, combination chemotherapy drugs, targeted biological drugs and antiangiogenics.

Real-World Results from Personalized TumorGrafts™

Case History — Dean, 63, Metastatic Pancreatic Cancer

Treatment history:

Dean underwent extensive abdominal surgery to take out a cancer of the pancreas, but the cancer recurred 12 months after surgery. Dean was treated with the most common treatment (i.e., standard of care), the anticancer drug Gemcitabine, for four months until the cancer began to grow despite treatment.

Personalized TumorGraft™ Insights:

Based on Personalized TumorGraft™ evaluations, one of the treatments tested was the anticancer drug mitomycin C — which is rarely used to treat pancreatic cancer. This treatment showed a significant response in the Personalized TumorGraft™.

Example of Personalized TumorGraft™ results, showing how two of the treatments were more effective than the other tested. (This case was published in Molecular Cancer Therapeutics, Villarroel et al.)2

Targeted Treatment Results:

Based on Personalized TumorGraft™ findings, Dean received three cycles of Mitomycin C. His blood tumor marker (used to measure the tumor in the blood) was previously 98,000 and based on TumorGraft directed treatments was reduced to under 100. After 22 months of Dean was treated with two additional cycles of Mitomycin C and three cycles of Cisplatin. Dean’s cancer has remained in remission — now five years after his surgery — Dean is still alive today. The average survival of patients with metastatic pancreatic cancer is approximately six to eight months.

Individual outcomes may vary.

Patients Share Their Success Stories

BETTY — Non-Small Cell Lung Cancer, London, UK

A combination of world-class advice and the data from the mice is ensuring that my oncologist has far more information about the potential effectiveness of various treatments than would normally be the case. I feel more in control and not a passive victim of my condition.

JACOB — Sarcoma, Toronto, Canada

Champions Oncology has given my family hope and strength. My husband finally has a fighting chance to beat the odds and survive his cancer. The physicians, coordinators, and entire staff at Champions have been extremely professional, caring, approachable, accessible, and very kind. As a wife, I will always be indebted to Champions for helping save my husband’s life. As a physician, I intend to help this phenomenal company make cancer a thing of the past! [Testimonial from Anne (Spouse)]

AMY — Metastatic Colon Cancer, Alabama, US

I’ve been to quite a few doctors in quite a few states and trying to find someone that could help me more than tell me to go home and take a chemotherapy and basically good luck. I can’t accept that — I’m a single mom, I’m 44 years old — I am not going to accept that answer. [After working with Champions] I’m so grateful that I can be with friends, my family, my son. It’s just been a really miraculous experience.

DAVID — Adenoid Cystic Carcinoma of Submandibular Gland, Israel

Thanks to Champions, I am treated now with Temodor, which seems to be very efficient. I cannot imagine how the physicians would come up with this solution using the conventional ways.

Individual outcomes may vary.

References:

  1. Hidalgo M et al. Activity of gemcitabine in direct patient derived xenografts predicts clinical outcome: validation of an in vivo model for drug development. J Clin Oncol 27:15s, 2009 (suppl; abstr 4528)
  2. Hidalgo M et al. A Pilot Study of Treatment Guided by Personalized Tumorgrafts in Patients with Advanced Cancer. Mol Cancer Ther August 2011 10:1311-1316
  3. Rubio-Viqueira B, Jimeno A, Cusatis G, et al. An in vivo platform for translational drug development in pancreatic cancer. Clin Cancer Res. 2006;12:4652-4661.
  4. Champions data on file.